id: pn_mapping_set:ubiquitin_proteasome_system label: Ubiquitin Proteasome System PN mappings references: - proteostasis-workbook-2024 - proteostasis-ms3 notes: Curated PN-to-GO mappings for high-confidence UPS context labels. These are primarily propagation mappings from PN context buckets to GO process, component, or activity terms. subject_curations: - subject_code: Ubiquitin Proteasome System subject_level: branch curation_status: no_mapping rationale: Reviewed as the top-level UPS branch. It is a project taxonomy umbrella rather than a direct GO assertion; UPS propagation must come from manually curated child nodes. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers subject_level: class curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E1 activating enzymes subject_level: class curation_status: context_only rationale: This class is a real ubiquitin-like modifier E1 context, but it spans ubiquitin, SUMO, NEDD8, UFM1, URM1, ISG15, FAT10, and autophagy modifiers. Propagation is safer from the curated child groups. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0008641 label: ubiquitin-like modifier activating enzyme activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes subject_level: class curation_status: context_only rationale: This class is a real E2/UBL transferase context, but it includes ubiquitin, SUMO, NEDD8, UFMylation, ATGylation, dual-use, and inactive buckets. Propagation is restricted to narrower curated children. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019787 label: ubiquitin-like protein transferase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases subject_level: class curation_status: context_only rationale: This class is a genuine E3-ligase context, but its descendants include catalytic ligases, cullin scaffolds, substrate receptors, adaptors, cofactors, regulators, and UBL modifier systems. A class-level propagation would over-annotate. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins subject_level: class curation_status: context_only rationale: This class records the proteasome branch context, but descendants include core and regulatory particle subunits, activators, assembly chaperones, adaptors, DUBs, E3 ligases, enzymes, and transcriptional regulators. Propagation should come from narrower nodes. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000502 label: proteasome complex mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding subject_level: class curation_status: context_only rationale: This class records ubiquitin/UBL-reader context, but the subtree mixes ubiquitin, SUMO, UBL-domain, domain-architecture, catalytic, signaling, trafficking, and nucleic-acid process buckets. It is useful context, not a safe direct propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0140036 label: ubiquitin-modified protein reader activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins subject_level: class curation_status: context_only rationale: This class groups ubiquitin, UBL modifiers, UBX/UBL-domain proteins, and UBL-containing enzymes. The branch is UPS-relevant but too mixed to propagate as a single GO annotation. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019787 label: ubiquitin-like protein transferase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|VCP and associated proteins subject_level: class curation_status: context_only rationale: This class records the VCP segregase branch context, but descendants include VCP, substrate adaptors, DUBs, E3 ligases, channels, and unrelated associated enzymes. Direct propagation is restricted to narrower nodes. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0043335 label: protein unfolding mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease subject_level: group curation_status: mapped rationale: This PN group is the ATG4 cysteine protease family. The shared defensible GO assertion is cysteine-type peptidase activity; autophagy-specific ATG8 processing is curated in the ALP branch. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0008234 label: cysteine-type peptidase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex subject_level: group curation_status: mapped rationale: This PN group denotes BRISC complex members. The matching GO cellular-component term is BRISC complex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0070552 label: BRISC complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex subject_level: group curation_status: mapped rationale: This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0008180 label: COP9 signalosome mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin subject_level: group curation_status: mapped rationale: This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY subject_level: group curation_status: mapped rationale: This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|MINDY, inactive subject_level: group curation_status: no_mapping rationale: Reviewed as an inactive or predicted-inactive DUB-family bucket. The domain/family relationship is real, but catalytic deubiquitinase propagation would be unsafe. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|OTU subject_level: group curation_status: context_only rationale: This OTU-family group is DUB-related context, but the subtree includes inactive or ambiguous OTU-like cases. Direct DUB propagation should come from narrower gene-level review rather than this whole family bucket. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|PPPDE subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|SENP subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|UCH subject_level: group curation_status: mapped rationale: This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP subject_level: group curation_status: mapped rationale: This PN group captures UFSP-family deUFMylases. The matching GO molecular-function term is deUFMylase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0071567 label: deUFMylase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP subject_level: group curation_status: mapped rationale: This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: ok_for_propagation_to_go excluded_subjects: - condition_level: type condition_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|deSUMOylation notes: The USP deSUMOylation subtype (USPL1) is excluded because it should not inherit generic deubiquitinase propagation. - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP, inactive subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|ZUP1 subject_level: group curation_status: mapped rationale: This PN group is an active deubiquitinase family bucket. The shared molecular-function assertion is deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E1 activating enzymes|activation of ATG8, ATG12 subject_level: group curation_status: mapped target_term: id: GO:0019778 label: Atg12 activating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group captures the autophagy-related E1 activation step for ATG8 and ATG12 family members. The GO Atg12 activating enzyme activity term is the specific propagation target supported by the local ontology cache. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E1 activating enzymes|activation of ISG15 subject_level: group curation_status: mapped target_term: id: GO:0008641 label: ubiquitin-like modifier activating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group represents E1 activation of the ubiquitin-like modifier ISG15. The generic GO ubiquitin-like modifier activating enzyme activity term is the appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E1 activating enzymes|activation of NEDD8 subject_level: group curation_status: mapped target_term: id: GO:0008641 label: ubiquitin-like modifier activating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group represents E1 activation of the ubiquitin-like modifier NEDD8. The generic GO activating enzyme activity term is the safest propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E1 activating enzymes|activation of SUMO subject_level: group curation_status: mapped target_term: id: GO:0008641 label: ubiquitin-like modifier activating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group represents E1 activation of the SUMO modifier family. The generic GO activating enzyme activity term is the safest propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E1 activating enzymes|activation of UFM1 subject_level: group curation_status: mapped target_term: id: GO:0008641 label: ubiquitin-like modifier activating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group represents E1 activation of the UFM1 modifier family. The generic GO activating enzyme activity term is the safest propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E1 activating enzymes|activation of URM1 subject_level: group curation_status: mapped target_term: id: GO:0008641 label: ubiquitin-like modifier activating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group represents E1 activation of the ubiquitin-like modifier URM1. The generic GO activating enzyme activity term is the safest propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E1 activating enzymes|activation of ubiquitin subject_level: group curation_status: mapped target_term: id: GO:0008641 label: ubiquitin-like modifier activating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group captures the canonical ubiquitin E1 activation step. The GO ubiquitin-like modifier activating enzyme activity term is the best propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E1 activating enzymes|activation of ubiquitin and FAT10 subject_level: group curation_status: mapped target_term: id: GO:0008641 label: ubiquitin-like modifier activating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group represents E1 activation of ubiquitin-family modifiers. The generic GO ubiquitin-like modifier activating enzyme activity term is the appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ATGylation subject_level: group curation_status: context_only rationale: This group captures ATG3/ATG10-like autophagy conjugation enzymes, but ATG8 and ATG12 conjugation require different precise terms. The group is kept as UBL-transferase context and should not propagate directly. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019787 label: ubiquitin-like protein transferase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|FAT10ylation subject_level: group curation_status: mapped rationale: This PN group is a UBL-conjugating E2 bucket. The safest shared molecular-function target is ubiquitin-like protein transferase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019787 label: ubiquitin-like protein transferase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|NEDDylation subject_level: group curation_status: mapped rationale: This PN group captures NEDD8-conjugating E2 enzymes. The matching GO molecular-function term is NEDD8 transferase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019788 label: NEDD8 transferase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|SUMOylation subject_level: group curation_status: mapped target_term: id: GO:0019789 label: SUMO transferase activity mapping_scope: ok_for_propagation_to_go rationale: This PN group captures SUMO-conjugating E2 enzymes. The local GO cache provides SUMO transferase activity as the closest supported molecular- function target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|UFMylation subject_level: group curation_status: mapped rationale: This PN group is a UBL-conjugating E2 bucket. The safest shared molecular-function target is ubiquitin-like protein transferase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019787 label: ubiquitin-like protein transferase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|inactive subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination subject_level: group curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: This PN group captures canonical ubiquitin E2 enzymes. The GO molecular- function term ubiquitin conjugating enzyme activity is the appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation subject_level: group curation_status: mapped rationale: This PN group contains dual ubiquitin/ISG15 E2 enzymes. Ubiquitin conjugating enzyme activity is the shared GO molecular-function target supported for this bucket. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator subject_level: group curation_status: context_only rationale: This PN group records regulation of cullin-RING ligase systems, but the members include inhibitors, exchange factors, and modulators with different directionality. It is context only. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1904666 label: regulation of ubiquitin protein ligase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate adaptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - file:human/KCTD18/KCTD18-ai-review.yaml - file:human/KCTD18/KCTD18-notes.md target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go excluded_subjects: - condition_level: gene_symbol condition_code: KCTD18 notes: >- KCTD18 is excluded after gene-level review because the local review finds its molecular function unknown. AlphaFold2 modeling predicts possible CUL3 binding, but there are no experimentally validated substrates, no validated CUL3 complex membership, and no direct evidence for ubiquitin-like ligase-substrate adaptor activity. - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold subject_level: group curation_status: mapped rationale: This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0160072 label: ubiquitin ligase complex scaffold activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - file:human/COP1/COP1-ai-review.yaml target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go notes: >- Gene-level review of COP1 (RFWD2) confirmed this propagation: it is a RING E3 with a C-terminal WD40 substrate-recognition module that selects substrates for the CRL4(DET1-COP1) ligase, supporting GO:1990756. - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - file:human/CRBN/CRBN-ai-review.yaml - file:human/DCAF11/DCAF11-ai-review.yaml target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go notes: >- Gene-level review of CRBN (cereblon) and DCAF11 confirmed this propagation: both are DDB1-CUL4 substrate-receptor subunits that present substrates for CRL4 ubiquitination, supporting GO:1990756 as the shared molecular-function target. - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul7 substrate receptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin subject_level: group curation_status: mapped rationale: This PN group captures cullin or cullin-associated scaffold roles in ubiquitin ligase complexes. The shared GO molecular-function target is ubiquitin ligase complex scaffold activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0160072 label: ubiquitin ligase complex scaffold activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor subject_level: group curation_status: mapped rationale: This PN group captures substrate receptors/adaptors for cullin/UBL ligase systems. The shared GO molecular-function target is ubiquitin-like ligase-substrate adaptor activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - file:human/ELOB/ELOB-ai-review.yaml - file:human/ELOC/ELOC-ai-review.yaml target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go excluded_subjects: - condition_level: gene_symbol condition_code: ELOB - condition_level: gene_symbol condition_code: ELOC notes: >- ELOB and ELOC are excluded after gene-level review because the Elongin BC module supports cullin-ligase assembly but is not itself the substrate-receptor activity captured by GO:1990756. Substrate recognition is supplied by BC-box, VHL-box, SOCS-box, or related receptor proteins. - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2 subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT activator subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT adaptor subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBX RING subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RCR subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifier cofactors subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers subject_level: group curation_status: context_only rationale: This group records UBL-modifier ligase context, but descendants include cofactors and idiosyncratic SUMOylation/ATGylation entries that are not uniformly transferase activities. Keep as context only. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019787 label: ubiquitin-like protein transferase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|cofactor for E3 with intrinsic E2 subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 subject_level: group curation_status: mapped rationale: This PN group is a catalytic ubiquitin E3 ligase bucket. The shared GO molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex subject_level: group curation_status: mapped rationale: This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000151 label: ubiquitin ligase complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex subject_level: group curation_status: mapped rationale: This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000151 label: ubiquitin ligase complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex subject_level: group curation_status: mapped rationale: This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000151 label: ubiquitin ligase complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex subject_level: group curation_status: mapped rationale: This PN group is an E3 ligase complex bucket. The safest shared GO target is ubiquitin ligase complex membership rather than assigning catalytic activity to every subunit. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000151 label: ubiquitin ligase complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors subject_level: group curation_status: mapped rationale: This PN group captures proteasome adaptors and shuttle factors. Proteasome binding is the safe shared molecular-function target. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0070628 label: proteasome binding mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB subject_level: group curation_status: mapped rationale: This PN group captures proteasome-associated deubiquitinases. The shared molecular-function target is deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase subject_level: group curation_status: mapped rationale: This PN group captures proteasome-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated non-Ub enzymes subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors subject_level: group curation_status: context_only rationale: This PN group mixes proteasome activators, inhibitors, and broader modulators. The proteasome relationship is real, but direct propagation should come from narrower activator/modulator nodes. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0070628 label: proteasome binding mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone subject_level: group curation_status: mapped rationale: This PN group captures proteasome assembly chaperones. The shared GO biological-process target is proteasome assembly. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0043248 label: proteasome assembly mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit subject_level: group curation_status: mapped rationale: This PN group captures proteasome core particle subunits. The matching GO cellular-component term is proteasome core complex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0005839 label: proteasome core complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit subject_level: group curation_status: mapped rationale: This PN group captures proteasome regulatory particle subunits. The matching GO cellular-component term is proteasome regulatory particle. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0005838 label: proteasome regulatory particle mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|regulators subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA & RNA dependent processes subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair subject_level: group curation_status: mapped target_term: id: GO:0006281 label: DNA repair mapping_scope: ok_for_propagation_to_go rationale: This PN group captures ubiquitin/UBL-binding factors assigned to DNA repair contexts. The group is context-defined rather than GO-equivalent, but propagation to DNA repair is appropriate. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication subject_level: group curation_status: mapped target_term: id: GO:0006260 label: DNA replication mapping_scope: ok_for_propagation_to_go rationale: This PN group is defined by ubiquitin/UBL-binding roles in DNA replication. The source category is narrower than the GO process itself and is therefore treated as a propagation mapping. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB subject_level: group curation_status: context_only rationale: This UBL-binding group is DUB-related context, but it includes noncatalytic or pseudo-DUB domain cases such as NPLOC4/USP39-like entries. Active DUB propagation is handled from the DUB-family branch. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB & E3 ligase subject_level: group curation_status: context_only rationale: This PN group is a dual DUB/E3 ligase bucket. The DUB relationship is real, but one GO target cannot capture both activities without losing information. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB cofactor subject_level: group curation_status: no_mapping rationale: Reviewed as a cofactor, possible adaptor, or related-family bucket. The label is useful in PN but does not establish a safe direct GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme subject_level: group curation_status: context_only rationale: This UBL-binding group contains E2 enzymes/domain contexts rather than a clean E2-binding activity bucket. E2 catalytic propagation is handled in the E2 conjugating enzyme branch. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme for SUMO subject_level: group curation_status: mapped rationale: This PN group identifies the SUMO E2 conjugating enzyme bucket. The matching GO molecular-function target is SUMO transferase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019789 label: SUMO transferase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme, inactive subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase subject_level: group curation_status: mapped rationale: This PN group captures ubiquitin/UBL-binding factors that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM subject_level: group curation_status: context_only rationale: This binding-branch group records E3/UBL-modifier context, but it includes cofactors as well as catalytic ligases. Direct propagation should come from narrower enzyme-specific nodes. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019787 label: ubiquitin-like protein transferase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase cofactor subject_level: group curation_status: no_mapping rationale: Reviewed as a cofactor, possible adaptor, or related-family bucket. The label is useful in PN but does not establish a safe direct GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component subject_level: group curation_status: mapped rationale: This PN group captures E3 ligase complex components. The safe shared GO target is ubiquitin ligase complex membership. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000151 label: ubiquitin ligase complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor subject_level: group curation_status: mapped target_term: id: GO:1990948 label: ubiquitin ligase inhibitor activity mapping_scope: ok_for_propagation_to_go rationale: This PN group captures UPS factors that inhibit E3 ligases. The matching GO activity term ubiquitin ligase inhibitor activity is the best supported propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 partial homolog subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|PEX1-PEX6 AAA ATPase complex subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor subject_level: group curation_status: mapped rationale: This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0070628 label: proteasome binding mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|endoribonuclease subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export subject_level: group curation_status: mapped target_term: id: GO:0016973 label: poly(A)+ mRNA export from nucleus mapping_scope: ok_for_propagation_to_go rationale: This PN group is a direct mRNA-export context bucket within the UPS branch. The GO mRNA export term is the specific target supported by the local ontology cache. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mitotic exit and cytokinesis subject_level: group curation_status: mapped target_term: id: GO:0000281 label: mitotic cytokinesis mapping_scope: ok_for_propagation_to_go rationale: This PN group is a direct mitotic-exit/cytokinesis context bucket within the UPS branch. The GO mitotic cytokinesis process is the appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|non-proteasomal proteases subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit subject_level: group curation_status: mapped rationale: This PN group captures ubiquitin/UBL-binding nuclear pore complex subunits. The matching GO cellular-component term is nuclear pore. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0005643 label: nuclear pore mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|possible proteasome adaptor subject_level: group curation_status: no_mapping rationale: Reviewed as a cofactor, possible adaptor, or related-family bucket. The label is useful in PN but does not establish a safe direct GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits subject_level: group curation_status: mapped rationale: This PN group captures ubiquitin/UBL-binding proteasomal subunits. The shared GO target is proteasome complex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000502 label: proteasome complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor subject_level: group curation_status: mapped rationale: This PN group captures proteasome adaptor/shuttle factors. Proteasome binding is the safe shared molecular-function target. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0070628 label: proteasome binding mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein phosphatases & regulators subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control subject_level: group curation_status: context_only rationale: This PN group is a protein-quality-control context bucket, but its descendants include ERAD cofactors, HSP70 cochaperone context, stalled-chain recognition, and other mixed roles. Direct propagation should come from narrower nodes such as ERAD cofactor. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0043161 label: proteasome-mediated ubiquitin-dependent protein catabolic process mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|putative RNA helicase subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|related to proteasome adaptor ZFAND5 subject_level: group curation_status: no_mapping rationale: Reviewed as a cofactor, possible adaptor, or related-family bucket. The label is useful in PN but does not establish a safe direct GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity, DUB cofactor subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation subject_level: group curation_status: context_only target_term: id: GO:0006412 label: translation mapping_scope: too_broad_to_propagate representative_genes: - TNRC6C - MDN1 - NACA2 - NACAD rationale: This PN group captures ubiquitin/UBL-binding factors assigned to translation-related contexts. The relationship to translation is real, but the group mixes heterogeneous subcontexts including repression, nascent-peptide binding, ribosome maturation, and ribosome-quality- control-adjacent roles. references: - proteostasis-workbook-2024 - proteostasis-ms3 notes: Gene-level projection showed that treating this as propagation-safe over-annotates mixed context genes such as TNRC6C, MDN1, NACA2, and NACAD as core translation factors. Keep the relationship visible, but do not project it as a candidate GO addition. - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain subject_level: group curation_status: context_only rationale: This group records UBL-domain protein context, but descendants include enzymes, adaptors, chaperone-related proteins, non-enzymatic proteins, and nucleic-acid factors. Propagation is restricted to narrower nodes. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0043130 label: ubiquitin binding mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain subject_level: group curation_status: no_mapping rationale: Reviewed as a UBX-domain protein bucket. UBX domain architecture is useful PN taxonomy but not itself a GO propagation target. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin subject_level: group curation_status: no_mapping rationale: Reviewed as the ubiquitin protein bucket. It identifies protein modifiers rather than a GO process, activity, or cellular component that should be propagated to the genes. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier subject_level: group curation_status: no_mapping rationale: Reviewed as a ubiquitin-like modifier protein bucket. The modifier identity is taxonomy context, not a safe GO annotation target for the modifier genes as a group. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|VCP subject_level: group curation_status: mapped rationale: This PN group is the VCP/p97 segregase node. The defensible shared GO target for VCP itself is protein unfolding. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0043335 label: protein unfolding mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors subject_level: group curation_status: context_only rationale: This PN group records VCP adaptor context, but it mixes UBX, SHP, VIM, VBM, membrane, and other adaptor classes. Direct propagation should come only from narrower complex-specific nodes or gene-level review. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0034098 label: VCP-NPL4-UFD1 AAA ATPase complex mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs subject_level: group curation_status: context_only rationale: This VCP-associated group is DUB-related context, but it includes NPLOC4 complex membership as well as catalytic DUBs. Direct DUB propagation comes from the DUB-family branch or narrower reviewed nodes. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases subject_level: group curation_status: mapped rationale: This PN group captures VCP-associated E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated channel proteins subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes subject_level: group curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease|lacking LIR subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|ATG4 cysteine protease|with LIR subject_level: type curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|catalytic subunit subject_level: type curation_status: mapped rationale: This PN type is the catalytic JAMM/MPN subunit of the BRISC complex. The shared molecular function is metal-dependent deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0140492 label: metal-dependent deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic subject_level: type curation_status: mapped rationale: This PN type covers noncatalytic BRISC subunits, so complex membership is the safe propagation target rather than catalytic DUB activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0070552 label: BRISC complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase subject_level: type curation_status: mapped rationale: This PN type covers COP9 signalosome members assigned to the deNEDDylase complex. Complex membership is safe for all members, whereas deNEDDylase activity is not safe for every subunit. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0008180 label: COP9 signalosome mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|CSN complex subject_level: type curation_status: mapped rationale: This PN group denotes COP9 signalosome/CSN complex members. The matching GO cellular-component term is COP9 signalosome. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0008180 label: COP9 signalosome mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|EIF3 complex subject_level: type curation_status: mapped target_term: id: GO:0005852 label: eukaryotic translation initiation factor 3 complex mapping_scope: ok_for_propagation_to_go rationale: This PN type captures JAMM/MPN proteins assigned to the eIF3 complex, notably proteostasis-linked eIF3 subunits with metalloprotease-like MPN domains. The GO eIF3 complex term is the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|USP dimerization domain subject_level: type curation_status: mapped rationale: This PN type groups catalytically active JAMM/MPN metalloprotease DUBs. The shared molecular-function target is metal-dependent deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0140492 label: metal-dependent deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|VCP-associated subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|assorted subject_level: type curation_status: mapped rationale: This PN type groups catalytically active JAMM/MPN metalloprotease DUBs. The shared molecular-function target is metal-dependent deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0140492 label: metal-dependent deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|JAMM / MPN|proteasomal subject_level: type curation_status: mapped rationale: This PN type captures the proteasomal JAMM/MPN deubiquitinase PSMD14/RPN11 context. The shared molecular-function target is metal-dependent deubiquitinase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0140492 label: metal-dependent deubiquitinase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin|UIM subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|Josephin|non-UIM subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|OTU|A20 subject_level: type curation_status: no_mapping rationale: Reviewed as an OTU-family subtype. Because the family branch includes inactive or ambiguous OTU-like cases, no automatic DUB propagation is made from this subtype. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|OTU|A20, UBA subject_level: type curation_status: no_mapping rationale: Reviewed as an OTU-family subtype. Because the family branch includes inactive or ambiguous OTU-like cases, no automatic DUB propagation is made from this subtype. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|OTU|RanBP2-type ZnF subject_level: type curation_status: no_mapping rationale: Reviewed as an OTU-family subtype. Because the family branch includes inactive or ambiguous OTU-like cases, no automatic DUB propagation is made from this subtype. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|OTU|UBL subject_level: type curation_status: no_mapping rationale: Reviewed as an OTU-family subtype. Because the family branch includes inactive or ambiguous OTU-like cases, no automatic DUB propagation is made from this subtype. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|OTU|inactive subject_level: type curation_status: no_mapping rationale: Reviewed as an OTU-family subtype. Because the family branch includes inactive or ambiguous OTU-like cases, no automatic DUB propagation is made from this subtype. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|OTU|other subject_level: type curation_status: no_mapping rationale: Reviewed as an OTU-family subtype. Because the family branch includes inactive or ambiguous OTU-like cases, no automatic DUB propagation is made from this subtype. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|PPPDE|deSUMOylase subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|PPPDE|deSUMOylase, DUB subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|SENP|deNEDDylase, NEDD8 processing subject_level: type curation_status: mapped rationale: This PN type is the SENP8/NEDD8-processing bucket. The matching GO molecular-function term is deNEDDylase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019784 label: deNEDDylase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|SENP|deSUMOylase subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|UFSP|deUFMylase subject_level: type curation_status: mapped rationale: This PN type is the explicit deUFMylase bucket under UFSP proteins. The matching GO molecular-function term is deUFMylase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0071567 label: deUFMylase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP, inactive|UBP-ZnF subject_level: type curation_status: no_mapping rationale: Reviewed as an inactive or predicted-inactive DUB-family bucket. The domain/family relationship is real, but catalytic deubiquitinase propagation would be unsafe. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP, inactive|Usp17 group subject_level: type curation_status: no_mapping rationale: Reviewed as an inactive or predicted-inactive DUB-family bucket. The domain/family relationship is real, but catalytic deubiquitinase propagation would be unsafe. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP, inactive|other subject_level: type curation_status: no_mapping rationale: Reviewed as an inactive or predicted-inactive DUB-family bucket. The domain/family relationship is real, but catalytic deubiquitinase propagation would be unsafe. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Ataxin-2, C term subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|CAP Gly-rich domain subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP, UBP-ZnF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|MATH-TRAF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|PH-like subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Rab-GTPase-TBC subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Usp17 group subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|deSUMOylation subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|dimerization, rhodanese-like subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|transmembrane subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|ZUP1|DUB subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ATGylation|no family designation subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower ATGylation family subdivision. The parent is context-only because ATG8 and ATG12 conjugation require different precise GO targets; no extra propagation is made from this family label. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|FAT10ylation|Family 14 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|NEDDylation|Family 8 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|SUMOylation|Family 7 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|UFMylation|no family designation subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|inactive|Family 10 subject_level: type curation_status: no_mapping rationale: Reviewed as an inactive E2-like family bucket. It should not propagate catalytic conjugating-enzyme activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|inactive|Family 16 subject_level: type curation_status: no_mapping rationale: Reviewed as an inactive E2-like family bucket. It should not propagate catalytic conjugating-enzyme activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|inactive|Family 9 subject_level: type curation_status: no_mapping rationale: Reviewed as an inactive E2-like family bucket. It should not propagate catalytic conjugating-enzyme activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation|Family 15 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation|Family 4 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 11 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 12 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 13 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 14 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 15 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17 homolog subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 2 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 5 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 6 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|CAND1 modulator subject_level: type curation_status: no_mapping rationale: Reviewed as a contextual, regulatory, adaptor, or uncertain UPS bucket. The shared label does not by itself establish a safe gene-level GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|CRL inhibitor subject_level: type curation_status: mapped rationale: This PN type captures cullin-RING ligase inhibitors. The matching GO process target is negative regulation of ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1904667 label: negative regulation of ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor subject_level: type curation_status: mapped rationale: This PN type captures CAND-family exchange factors that activate/remodel cullin-RING ligase assemblies. The closest shared GO activity is ubiquitin ligase activator activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990757 label: ubiquitin ligase activator activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|BTRC specific subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|FBXL2/FBXL20 specific subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|SKP2 specific subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|non-canonical subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|non-canonical subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate adaptor|KLHL12 specific subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / other subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold|(no type) subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|non-canonical subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul7 substrate receptor|F-box, noncanonical contact subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor|DDB1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor|Elongin BC complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin adaptor|Skp1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|canonical subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, APC sununit subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|degenerate, possible CUL3 inhibitor subject_level: type curation_status: no_mapping rationale: Reviewed as a contextual, regulatory, adaptor, or uncertain UPS bucket. The shared label does not by itself establish a safe gene-level GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cullin|metazoan subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2|BIR repeat subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|E3 with intrinsic E2|other subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT activator|ITCH-specific, transmembrane subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT activator|transmembrane subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT adaptor|MAGE subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT adaptor|arrestin subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT adaptor|non-MAGE, non-arrestin subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|Armadillo-like, WWE subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|Armadillo-like, WWE, UBA subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|Armadillo-like, ankyrin repeats subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|DOC subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|FIL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|IQ motif subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|PHD subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|UBR-type ZnF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|ankyrin repeats subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|other subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|transmembrane, SPRY subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|Ariadne subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|Ariadne, ankyrin repeats, UIM subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|Cullin, Armadillo-like subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|PUB, RanBP2-type ZnF, UBA subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|RWD subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|UBL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|UBL, RanBP2-type ZnF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|other subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RBR|transmembrane subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|MAGE subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|other subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|C4C4 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD variant subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BIRC / IAP subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BRCA1 & associated subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|CBL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Hakai subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|IRF2 binding subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|LON subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MEX3 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Makorin subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mdm subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mindbomb subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|NFX subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Neuralized subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PEX subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Pellino subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Praja subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RFWD subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RNF20/40 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Roquin subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SAP subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SH3 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SIAH / SINA subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SUMO binding domain subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAC-1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class II subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class III subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IX subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VI subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VII subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VIII subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class X subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class XI subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UBR subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UHRF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Unkempt subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ZNRF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding & transmembrane subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ|RNA helicase subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RZ|dynein-like motor subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifier cofactors|SUMOylation cofactor subject_level: type curation_status: no_mapping rationale: Reviewed as a contextual, regulatory, adaptor, or uncertain UPS bucket. The shared label does not by itself establish a safe gene-level GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifier cofactors|UFMylation cofactor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|ATGylation subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|ISG15ylation subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|NEDDylation subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|SUMOylation subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|UFMylation subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|cofactor for E3 with intrinsic E2|histone chaperone subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|C2H2 ZnF (one cluster) subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|C2H2 ZnF (two clusters) subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|LIM, PDZ subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|OTU & A20 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|bromodomain, Acyl_CoA_acyltransferase subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|other subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|proposed HECT variant subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3|transcription factor subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC subject_level: type curation_status: mapped rationale: This PN type denotes the LUBAC RBR E3 ligase complex. The safe GO propagation target is ubiquitin ligase complex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000151 label: ubiquitin ligase complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex subject_level: type curation_status: mapped target_term: id: GO:0005680 label: anaphase-promoting complex mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, APC/C is nested under the idiosyncratic RING-complex branch rather than appearing as a direct group. The GO cellular-component term anaphase-promoting complex remains the appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex subject_level: type curation_status: mapped rationale: This PN type denotes BRCA1-A complex members. The matching GO cellular-component term is BRCA1-A complex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0070531 label: BRCA1-A complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1/BARD complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|KPC complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex|STUB1/CHIC2 complex subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|BAG subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|PB1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|antizyme subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB|UCH subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated DUB|USP subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|HECT subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|RING, UBL subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|UBR subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated non-Ub enzymes|aspartic peptidase subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated non-Ub enzymes|chaperone subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated non-Ub enzymes|deglycosylase subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated non-Ub enzymes|reductase subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated non-Ub enzymes|tetrapyrrole biosynthesis subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA subject_level: type curation_status: mapped target_term: id: GO:0070628 label: proteasome binding mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the proteasome activator bucket is now the AAA-type activator subtype under proteasome activators and inhibitors. The local GO cache does not expose a proteasome-activator activity term, so proteasome binding is the most conservative supported target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator subject_level: type curation_status: mapped target_term: id: GO:0070628 label: proteasome binding mapping_scope: ok_for_propagation_to_go rationale: The earlier inhibitor bucket is no longer present in `4.3.11`; the surviving coarse category is proteasome modulator. The local GO cache lacks a specific proteasome-modulator activity term, so proteasome binding is the conservative propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|core particle subject_level: type curation_status: mapped target_term: id: GO:0043248 label: proteasome assembly mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes assembly chaperones for the proteasome core particle. The GO proteasome assembly process is the appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle subject_level: type curation_status: mapped target_term: id: GO:0043248 label: proteasome assembly mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes assembly chaperones for the proteasome regulatory particle. The local GO cache does not expose a regulatory-particle assembly term, so the broader proteasome assembly process is the correct conservative target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit subject_level: type curation_status: mapped rationale: This PN type captures alpha-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, alpha-subunit complex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019773 label: proteasome core complex, alpha-subunit complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit subject_level: type curation_status: mapped rationale: This PN type captures beta-subunit proteasome core members. The matching GO cellular-component term is proteasome core complex, beta-subunit complex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0019774 label: proteasome core complex, beta-subunit complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase subject_level: type curation_status: mapped rationale: This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0008540 label: proteasome regulatory particle, base subcomplex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase subject_level: type curation_status: mapped rationale: This PN type captures base subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, base subcomplex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0008540 label: proteasome regulatory particle, base subcomplex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase subject_level: type curation_status: mapped rationale: This PN type captures lid subunits of the proteasome regulatory particle. The matching GO cellular-component term is proteasome regulatory particle, lid subcomplex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0008541 label: proteasome regulatory particle, lid subcomplex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|regulators|transcription factor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA & RNA dependent processes|DNA/RNA binding protein subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|5'-tyrosyl DNA phosphodiesterase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRCA1-A complex component subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRISC complex component subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA binding subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA damage signalling subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA endonuclease subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA endonuclease cofactor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA exonuclease subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA glycosylase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA helicase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA polymerase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA protein crosslink recognition subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA repair accessory subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|RNA polymerase II removal subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|binding to damaged DNA subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|cohesin loading subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|dCTP transferase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNA polymerase accessory subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNA polymerase clamp loader subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNE endonuclease and helicase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB & E3 ligase|OTU & idiosyncratic E3 ligase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB cofactor|USP10 subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|Josephin subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|MINDY subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|MPN & UBXL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|OTU subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|PPPDE subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|SENP subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / DUSP subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / MATH-TRAF, external UBL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / PH-like domain subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / with Armadillo & UBL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / with UBD subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|idiosyncratic DUB subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme for SUMO|Family 7 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme, inactive|Family 10 subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 1 subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 17 subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 2 subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 3 subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 4 subject_level: type curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|NEDDylation subject_level: type curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|SUMOylation subject_level: type curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|UFMylation cofactor subject_level: type curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase cofactor|RAP80 NTD subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase cofactor|SUMOylation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|APC / catalytic subunit subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|FANC / catalytic subunit subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|LUBAC subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|idiosyncratic / noncatalytic subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor|ITCH inhibitor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL5 receptor subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|E3 with intrinsic E2 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / Armadillo-like, WW subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / HERC-type / RCC1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / RCC1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / with IQ subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Ariadne subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Cullin subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / LUBAC subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / PUB subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / with UBD subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BIRC, IAP subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BRCA1 & associated subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / CBL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Mdm subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Praja subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / SAP subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / SUMO binding domain subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRAC-1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRIM class IV subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRIM class V subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / ZNRF subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / second enzymatic function subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD & TM subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING variant / UBOX subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 partial homolog|related to RNF111 subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|PEX1-PEX6 AAA ATPase complex|peroxisomal membrane subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor|with AN1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|PLA2 activator subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBL subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBX subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBX & TRX-like subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBX, SHP subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated|PAF regulator subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated|adapter, membrane proteins subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated|kinetochore motor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated|other subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|endoribonuclease|antiviral response subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|endoribonuclease|inflammatory response subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export|mRNA export subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing subject_level: type curation_status: mapped target_term: id: GO:0048024 label: regulation of mRNA splicing, via spliceosome mapping_scope: ok_for_propagation_to_go rationale: This PN type is a direct mRNA-splicing context bucket within the UPS branch. The GO splicing-regulation term is the supported propagation target in the local cache. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|polyadenylation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mitotic exit and cytokinesis|mitotic exit and cytokinesis subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|non-proteasomal proteases|aspartic protease with UBL subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|non-proteasomal proteases|endopeptidase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|non-proteasomal proteases|serine protease subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit|GATOR2 complex subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit|mRNA, protein export subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|DNA nicking endonuclease subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling subject_level: type curation_status: mapped target_term: id: GO:0006338 label: chromatin remodeling mapping_scope: ok_for_propagation_to_go rationale: This PN type groups ubiquitin/UBL-binding factors assigned to chromatin remodeling. The source is a context bucket rather than a canonical GO class, so propagation scope is appropriate. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|persulfide transfer subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|promotes nitric oxide synthesis subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers|ADP ribosyltransferase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers|N-terminal acetylation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers|dipeptidyl peptidase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers|histone deacetylase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|possible proteasome adaptor|with UBL subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle subject_level: type curation_status: mapped rationale: This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0005838 label: proteasome regulatory particle mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1 subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|AMP-activated Ser/Thr kinases subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|GATOR2 complex subject_level: type curation_status: mapped target_term: id: GO:0061700 label: GATOR2 complex mapping_scope: ok_for_propagation_to_go rationale: This PN type identifies ubiquitin/UBL-binding factors assigned to the GATOR2 complex. The GO cellular-component term GATOR2 complex is an appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|microtubule-associated Ser/Thr kinases subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|regulator of IR tyrosine kinase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|salt-inducible Ser/Thr kinases subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|tyrosine kinase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein phosphatases & regulators|phosphatase regulator subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein phosphatases & regulators|phosphatidylinositol phosphatase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein phosphatases & regulators|tyrosine phosphatase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor subject_level: type curation_status: mapped target_term: id: GO:0097466 label: ubiquitin-dependent glycoprotein ERAD pathway mapping_scope: ok_for_propagation_to_go rationale: This PN type groups ubiquitin/UBL-binding factors that act as ERAD cofactors in protein-quality-control contexts. The best available GO target in the local cache is ubiquitin-dependent glycoprotein ERAD pathway, used here at propagation scope. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|HSP70 cochaperone subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|protein folding & quality control subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|stalled chain recognition subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|putative RNA helicase|putative RNA helicase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|related to proteasome adaptor ZFAND5|with AN1 subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity, DUB cofactor|inhibits NF-kappa-B activation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|IKK core complex subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|Inhibits NF-kappa-B activation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|TAK1 kinase substrate adaptor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|TBK1 kinase substrate adaptor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|antigen recognition / GAP & GEF subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|bacterial component sensor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|modulator of NEMO subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|receptor in AKT signaling cascade subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|viral dsRNA sensor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|viral nucleic acid sensor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling|GAP subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling|activates the PI3K/AKT pathway subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|EGFR internalization subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ERphagy subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-0 complex subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-I complex subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-I complex cofactor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-II complex subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|MYO6 adapter subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|Rab effector subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|adapter subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|clathrin proximal subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|endoprotease subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|endoprotease (probable) subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|endycytosis adapter subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|exocytosis subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|late endosomes subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|lipophagy subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|macroautophagy subject_level: type curation_status: context_only rationale: This PN type is an autophagy-related trafficking context, but the earlier TRAPP review showed that generic autophagy propagation from component or binding-context buckets can be too strong. Keep as context unless gene-level evidence supports macroautophagy. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0016236 label: macroautophagy mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|mitophagy subject_level: type curation_status: context_only rationale: This PN type records a mitophagy-related trafficking context. The relationship is biologically real, but automatic mitophagy propagation from a UPS binding bucket is too strong without gene-level review. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0000423 label: mitophagy mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|motor protein / ATPase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|phospholipid binding subject_level: type curation_status: mapped target_term: id: GO:0005543 label: phospholipid binding mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes ubiquitin/UBL-binding factors additionally assigned to phospholipid binding in trafficking contexts. The matching GO molecular function is a reasonable propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|probable adapter subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|selective autophagy subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|transporter regulator subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|DNA binding subject_level: type curation_status: mapped target_term: id: GO:0003677 label: DNA binding mapping_scope: ok_for_propagation_to_go rationale: This PN type groups ubiquitin/UBL-binding factors assigned to transcriptional DNA-binding contexts. Propagation to GO DNA binding is appropriate, with the caveat that the PN source is context-defined. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation (probable) subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation and repression subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|coactivation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|coactivation and corepression subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|corepression subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|initiation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|nuclear hormone receptor subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|regulator subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|repression subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|mitochondrial subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|nascent peptide binding subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|repression subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|ribosome QC & DNA repair subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|ribosome QC & transcriptional activation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|ribosome maturation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|translational upregulation subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB subject_level: type curation_status: context_only rationale: This UBL-domain type is DUB-related context, but the subtree includes noncatalytic MPN/UBL-domain cases. Active DUB propagation is handled from the DUB-family branch. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB modulator subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases subject_level: type curation_status: context_only rationale: This UBL-domain type is an E3-ligase context, but descendants include catalytic E3s as well as cullin receptor/adaptor components. Direct propagation is restricted to narrower subtypes. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: too_broad_to_propagate - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|SUMO activation subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|activation of ISG15 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|activation of NEDD8 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|activation of ubiquitin subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|activation of ubiquitin and FAT10 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|chaperones and related subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|other enzymes subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|transmembrane subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquilin-like subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding subject_level: type curation_status: mapped target_term: id: GO:0043130 label: ubiquitin binding mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes UBL-domain proteins assigned to ubiquitin-binding roles. The matching GO molecular-function term ubiquitin binding is the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|ATG12 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|ATG8 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|FAT10 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|FAU subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|ISG15 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|NEDD8 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|SUMO subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|UBL3 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|UBL5 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|UFM1 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin-like modifier|URM1 subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin|polyubiquitin subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|ubiquitin|ribosomal ubiquitin fusion subject_level: type curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|SHP subject_level: type curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX subject_level: type curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX, PUB, VIM subject_level: type curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX, SHP subject_level: type curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX, SHP, UBXL subject_level: type curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|VBM subject_level: type curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|VIM subject_level: type curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|Josephin subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated DUB/adaptor subdivision. The VCP context includes both catalytic DUBs and noncatalytic complex members, so no additional direct DUB propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|MPN subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated DUB/adaptor subdivision. The VCP context includes both catalytic DUBs and noncatalytic complex members, so no additional direct DUB propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|OTU subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated DUB/adaptor subdivision. The VCP context includes both catalytic DUBs and noncatalytic complex members, so no additional direct DUB propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RBR subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated E3 architecture subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RING subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated E3 architecture subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|UBOX subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated E3 architecture subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated channel proteins|SHP subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes|PLA2 activator subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes|deglycolsylase subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes|metalloprotease subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes|serine protease subject_level: type curation_status: no_mapping rationale: Reviewed as a UPS taxonomy container. Its descendants mix catalytic roles, complex membership, binding domains, regulators, adaptors, and substrate-context labels, so a single propagating GO assertion would overstate the shared biology. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|catalytic subunit|JAMM / MPN subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|JAMM / MPN / ubiquitin binding subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|other / RCC1, SPRY, WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|ubiquitin binding subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|MPN, catalytic subunit subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|MPN, noncatalytic subunit subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|PCI subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|CSN complex|deNEDDylase|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like|external UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like|external UBL, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Armadillo-like|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Ataxin-2, C term|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|CAP Gly-rich domain|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP|external UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|DUSP|internal and external UBLs subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|MATH-TRAF|external UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|PH-like|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|PH-like|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|Rab-GTPase-TBC|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|UBP-ZnF|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|dimerization, rhodanese-like|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|UBA, UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|external UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|internal UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|other|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|transmembrane|internal UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|DUBs and UBL demodifiers|USP|transmembrane|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower active DUB family/domain subdivision already covered by the curated parent DUB-family mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|FAT10ylation|Family 14|UBC domain & N-terminal and C-terminal extensions subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|inactive|Family 10|(none) subject_level: subtype curation_status: no_mapping rationale: Reviewed as an inactive E2-like family bucket. It should not propagate catalytic conjugating-enzyme activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|inactive|Family 16|(none) subject_level: subtype curation_status: no_mapping rationale: Reviewed as an inactive E2-like family bucket. It should not propagate catalytic conjugating-enzyme activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|inactive|Family 9|(none) subject_level: subtype curation_status: no_mapping rationale: Reviewed as an inactive E2-like family bucket. It should not propagate catalytic conjugating-enzyme activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation|Family 15|UBC domain only subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination, ISG15ylation|Family 4|UBC domain & N-terminal extension subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 11|UBC domain & C-terminal extension subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 12|UBC domain & N-terminal extension subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The N-terminal extension does not change the core E2 activity assignment. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 13|UBC domain only subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 14|E2-E3 chimera subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, E2 architectural variants are modeled as family-specific subtypes beneath the ubiquitination group. This condition-scoped subtype mapping preserves the original intent across any family carrying the E2-E3 chimera architecture. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 15|UBC domain only subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17 homolog|UBC domain only subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 17|UBC domain & RWD-like domain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 1|UBC domain & UBA domain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E2 family or architecture subdivision already covered by the curated parent E2 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 2|UBC domain only subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain & C-terminal extension subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 3|UBC domain only subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & C-terminal extension subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain & N-terminal extension subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The N-terminal extension does not change the core E2 activity assignment. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 4|UBC domain only subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 5|UBC domain & transmembrane domain subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, this membrane-anchored architecture appears as a family-specific subtype beneath the ubiquitination group. The structural specialization does not change the core conjugating activity. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 6|UBC domain & C-terminal extension subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9|UBC domain & C-terminal extension subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, this architecture appears as a family-specific subtype under the ubiquitination group. The structural specialization does not change the core E2 molecular function. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E2 conjugating enzymes|ubiquitination|Family 9|UBC domain only subject_level: subtype curation_status: mapped target_term: id: GO:0061631 label: ubiquitin conjugating enzyme activity mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the minimal UBC-domain architecture appears as a family-specific subtype beneath the ubiquitination group. The core GO activity term remains the correct propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|CRL regulator|F-box exchange factor|Armadillo-like subject_level: subtype curation_status: mapped rationale: This PN type captures CAND-family exchange factors that activate/remodel cullin-RING ligase assemblies. The closest shared GO activity is ubiquitin ligase activator activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990757 label: ubiquitin ligase activator activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|SKP2 specific|MAGE subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate adaptor|SKP2 specific|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|CASH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|CASH, UBR-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|DNA helicase subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|FBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|KELCH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|LRR with PHD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|PI31, UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|RCC1 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|TRAF-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|ZBR-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul1 substrate receptor|F-box|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZER1 group / Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate adaptor|VHL box|ZSWIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|KELCH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|LRR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|PRAME (with LRR) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|VHL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ZER1 group / Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ZER1 group / Armadillo-like, LRR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|VHL box|ankyrin repeat subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul2 substrate receptor|non-canonical|with LRR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate adaptor|KLHL12 specific|EF hand subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|KCTD11/21 CTD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / KCTD type I|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB / other|Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|KELCH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|RCC1 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin, transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|GCL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|KELCH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|MATH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|PHR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|RCC1 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|ankyrin subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|ankyrin, RCC1 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK|small GTPase subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B receptor scaffold|(no type)|(no subtype) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|PAS subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|AHR / ARNT / TBL3 complex|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|IQ motif subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|LisH, Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|bromodomain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|LON, Yippee, DOC subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|non-WD40|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box|LRR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box|NHR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box|SH2 domain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box|SPRY domain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box|ankyrin repeat subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|SOCS box|small GTPase subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul5 substrate receptor|non-canonical|with KELCH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul7 substrate receptor|F-box, noncanonical contact|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower substrate-receptor, adaptor, domain, or family subdivision already covered by the curated parent adaptor/receptor mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT adaptor|MAGE|HUWE1-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT adaptor|non-MAGE, non-arrestin|HERC2-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT adaptor|non-MAGE, non-arrestin|HUWE1-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|DOC subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|WD40, SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|HERC-type / RCC1|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|HECT|NEDD4-type / WW & C2|ubiquitination & NEDDylation subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|MAGE|LNX1-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|MAGE|NSE1-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|MAGE|PRAJA1-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|MAGE|TRIM27- and RNF41-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|MAGE|TRIM28-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|MAGE|TRIM31-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|MAGE|TRIM69-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|other|MDM2-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|other|RNF220-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|other|TRAF2-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING cofactor|other|TRIM22-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD variant|UBR-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|SET subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|PHD|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|RING (non-overlapping) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING variant|UBOX|split UBOX subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BIRC / IAP|BIR repeat subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BRCA1 & associated|BRCT subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|BRCA1 & associated|UBP-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|CBL|PTB subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|CBL|PTB, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex|WWE subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Deltex|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Goliath|PA, transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|LON|TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|MARCH|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Makorin|C3H1-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Mdm|RanBP2-type ZNF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|NFX|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|NFX|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Neuralized|SPRY / NHR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|TRAF-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PDZ|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|PEX|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Polycomb|RAWUL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|RFWD|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Roquin|C3H1-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SIAH / SINA|SIA TRAF-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|Armadillo subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL Group 1 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL Group 2 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|RFPL other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|SPRY but not TRIM|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|MATH/TRAF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRAF-type ZnF|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class III|COS, FN subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class II|COS subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV homolog|SPRY - folded central helix subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|SPRY - folded central helix subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IV|no CTD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class IX|ARF, P-loop NTP hydrolase subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class I|COS, FN, SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VIII|MATH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VII|FIL, TolB-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VII|TolB-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class VI|PHD-type ZnF, Bromodomain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|TolB-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|no CTD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|no CTD & folded helix subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|no CTD & short central helix subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class V|various CTD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class XI|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / class X|FIL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|Pyrin, ringless, SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & FN & SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & SPRY & folded central helix subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & assorted CTD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|TRIM / unclassified|ringless & no CTD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UBR|UBR CTD, UBR-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|UBR|UBR CTD, UBR-type ZnF, TM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|Unkempt|C3H1-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|VPS-associated|non-WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ZNRF|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ZNRF|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|C3H1-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|FHA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|LRR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|SWIM-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|TOL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|other|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|Histone-lysine N-methyltransferase subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|P-loop NTP hydrolase & transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|RAG complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|helicase subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|kinase, SWIM-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|second enzymatic function|kinase, bromodomain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding & transmembrane|ER subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|TTC3/DZIP3 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|TTC3/DZIP3, TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|ubiquitin binding domain|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, Golgi subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, Golgi, lysosome subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, mitochondria subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, mitochondria, cell membrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, nuclear envelope subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|ER, nuclear envelope, cell membrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|Golgi subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|acrosome, secretory vescicle subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|cytoplasm subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|lysosome subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|RING|with transmembrane domain|mitochondria, peroxisome subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifier cofactors|UFMylation cofactor|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|ISG15ylation|HECT (RCC1) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|ISG15ylation|RBR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|ISG15ylation|TRIM (SPRY) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|NEDDylation|PONY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|SUMOylation|MIZ / PIAS group subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|SUMOylation|MIZ / ZMIZ group subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|SUMOylation|MIZ / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|SUMOylation|idiosyncratic subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|UBL modifiers|SUMOylation|non-MIZ subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-modifier subtype or architecture bucket. The subtree mixes catalytic ligases with cofactors/idiosyncratic contexts, so no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|cofactor for E3 with intrinsic E2|histone chaperone|UBE2O-specific subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|catalytic subunit subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic E3 ligase complex|UBR4/KCMF1 complex|noncatalytic subunit subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC|catalytic / RBR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RBR complex|LUBAC|noncatalytic / UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|catalytic / RING subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|catalytic / core subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / DOC subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|noncatalytic / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|Anaphase Promoting Complex|substrate adaptor / WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|DUB / MPN subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|catalytic / RING subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|other / RCC1, SPRY, WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|BRCT subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|DNA helicase subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-B complex|catalytic / RING subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|DNA endonuclease subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex / ATPase subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex / BRCT subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|MRN subcomplex / DNA binding subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-C complex|catalytic / RING subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1/BARD complex|catalytic / RING subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|catalytic / RING, CRA, LisH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / CRA, LisH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / CRA, LisH, SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / LisH, KELCH subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / LisH, WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / Yippee subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|CTLH complex|noncatalytic / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|catalytic / RING subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|FANC core complex|noncatalytic / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|KPC complex|catalytic / RING, SPRY subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|KPC complex|noncatalytic / UBL, UBA, STI subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|catalytic / UBOX, transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|noncatalytic / UBA, transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|LMBR1L-GP78-UBAC2 complex|noncatalytic / transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex|catalytic / RING subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|MSL1/MSL2 complex|noncatalytic / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|catalytic / RING, transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|RNF170 / ERLIN complex|noncatalytic / BAND 7 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|catalytic / RING, transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|membralin complex|noncatalytic / transmembrane, UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex|STUB1/CHIC2 complex|catalytic / UBOX / TPR subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|idiosyncratic UBOX complex|STUB1/CHIC2 complex|noncatalytic subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower E3-ligase architecture, component, or domain subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|A20 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|UBZ subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|AN1|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|PB1|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|UBL only subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|UBL|with UBA, STI subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|HECT|Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|associated E3 ligase|UBR|UBR-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|activator, AAA|PA28 subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|PI31 subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome activators and inhibitors|modulator|PITH subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|PDZ subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome assembly chaperone|regulatory particle|ankyrin subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|constitutive subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|alpha subunit|specialized subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|constitutive subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome core particle subunit|beta subunit|specialized subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, ATPase|with OB domain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|Armadillo-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|PRU, DEUBAD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|VWA, UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|MPN subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|PCI subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|proteasome regulatory particle subunit|lid, nonATPase|SEM1 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome component, chaperone, adaptor, domain, or isoform subdivision already covered by a curated parent proteasome mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|regulators|transcription factor|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Proteasome and associated proteins|regulators|transcription factor|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA & RNA dependent processes|DNA/RNA binding protein|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|5'-tyrosyl DNA phosphodiesterase|UBA-like (TDP2) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRCA1-A complex component|idiosyncratic Ub binding / MPN subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRCA1-A complex component|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|BRISC complex component|idiosyncratic Ub binding / MPN subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA binding|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA damage signalling|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA endonuclease cofactor|UIM, UBZ4-type ZnF, SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA endonuclease|UBM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA exonuclease|UBZ4-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA glycosylase|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA glycosylase|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA helicase|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA helicase|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA polymerase|UBM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA polymerase|UBZ3-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA polymerase|UBZ4-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA protein crosslink recognition|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA repair accessory|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA repair accessory|UBZ2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|DNA repair accessory|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|RNA polymerase II removal|UBA (UBAP2) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|binding to damaged DNA|UBZ (XPA) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|binding to damaged DNA|idiosyncratic Ub binding / alpha solenoid subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|cohesin loading|UBM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA repair|dCTP transferase|UBM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNA polymerase accessory|UBZ4-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNA polymerase clamp loader|tandem MIU subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DNA replication|DNE endonuclease and helicase|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB & E3 ligase|OTU & idiosyncratic E3 ligase|A20 ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB cofactor|USP10|UBZ1-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|Josephin|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|Josephin|UIM, SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|MINDY|MIU subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|MPN & UBXL|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|OTU|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|OTU|UBA (OTUD7A/B), A20 ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|OTU|UBA-like (other) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|OTU|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|PPPDE|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|SENP|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / DUSP|UBP-associated ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / MATH-TRAF, external UBL|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / PH-like domain|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / with Armadillo & UBL|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / with UBD|UBA, UBP-associated ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / with UBD|UBP-associated ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / with UBD|UIM, UBA-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|USP / with UBD|UIM, UBA-like, SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|DUB|idiosyncratic DUB|MIU, UBZ, zUBD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-binding DUB-domain subdivision. Because this subtree includes noncatalytic or pseudo-DUB cases, active DUB propagation is handled by the DUB-family branch rather than this binding-domain node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme for SUMO|Family 7|backside SUMO binding subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme, inactive|Family 10|UEV, backside Ub binding subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 17|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 1|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 2|backside Ub binding subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 3|backside Ub binding subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E2 conjugating enzyme|Family 4|backside Ub binding subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBL-binding/domain subdivision of E2 enzymes. It is already covered by the curated E2 branch where appropriate, and this node should not propagate E2-binding activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|NEDDylation|UBA-like (DCNL1) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|NEDDylation|UBA-like (DCNL2) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|SUMOylation|RanBP2-type ZnF, SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|SUMOylation|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|SUMOylation|UIM, SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase / UBLM|UFMylation cofactor|UFM1 binding subject_level: subtype curation_status: no_mapping rationale: Reviewed as a binding-branch UBL-modifier subtype. Because this context mixes catalytic ligases and cofactors, no direct GO propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase cofactor|RAP80 NTD|UIM, UBZ4-type ZnF, SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase cofactor|SUMOylation|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|APC / catalytic subunit|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|FANC / catalytic subunit|idiosyncratic Ub binding / ELF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|LUBAC|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase complex component|idiosyncratic / noncatalytic|UBZ (Di19) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase inhibitor|ITCH inhibitor|UBA (N4BP1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL1 receptor|idiosyncratic Ub binding / WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|CUL5 receptor|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|E3 with intrinsic E2|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / Armadillo-like, WW|UIM, UBM, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / HERC-type / RCC1|ZZ Zinc finger (SUMO binding), UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / RCC1|UBR-type ZnF, CUE (UBR5) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|HECT / with IQ|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Ariadne|UBA-like (ARIH1) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Ariadne|UIM, UBA-like (ARIH1) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / Cullin|UBA-like (ARIH1) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / LUBAC|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / PUB|UBA, RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / with UBD|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RBR / with UBD|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BIRC, IAP|UBA (BIRC2/3) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BRCA1 & associated|UBP-associated ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / BRCA1 & associated|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / CBL|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Mdm|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / Praja|idiosyncratic Ub binding / zinc ribbon subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / SAP|UBZ4-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / SUMO binding domain|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRAC-1|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRIM class IV|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / TRIM class V|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / ZNRF|UBZ (ZNRF1/2) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / second enzymatic function|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD & TM|CUE subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|MIU subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|RWD (LTN1) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|UBA-like (other) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING / with UBD|UBZ (RNF220) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 ligase|RING variant / UBOX|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower enzyme-family, domain, or architecture subdivision already covered by a curated parent enzyme mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|E3 partial homolog|related to RNF111|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|PEX1-PEX6 AAA ATPase complex|peroxisomal membrane|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP and proteasome adaptor|with AN1|UIM, UBZ (ZFAND2A/B) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|PLA2 activator|idiosyncratic Ub binding / PFU & WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBL|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBX & TRX-like|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBX & TRX-like|UBA-like subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBX & TRX-like|UIM, UBA-like subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBX, SHP|UBA-like (p47) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|VCP-associated adaptor|with UBX|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated|PAF regulator|idiosyncratic Ub binding / WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated|adapter, membrane proteins|idiosyncratic Ub binding / SH3 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated|kinetochore motor|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|cytoskeleton associated|other|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|endoribonuclease|antiviral response|UBA (N4BP1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|endoribonuclease|inflammatory response|UBA-like (Rege-1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA export|mRNA export|UBA-like (TAC) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|UBA-like (other) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|idiosyncratic Ub binding / MPN subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|mRNA splicing|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mRNA maturation|polyadenylation|idiosyncratic Ub binding / WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|mitotic exit and cytokinesis|mitotic exit and cytokinesis|UBAN-like, UBZ-like subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|non-proteasomal proteases|aspartic protease with UBL|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|non-proteasomal proteases|endopeptidase|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|non-proteasomal proteases|endopeptidase|UBZ4-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|non-proteasomal proteases|serine protease|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit|GATOR2 complex|SUMO binding / WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|nuclear pore complex subunit|mRNA, protein export|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|DNA nicking endonuclease|CUE subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling|CUE subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other DNA dependent processes|chromatin remodeling|idiosyncratic Ub binding / other subject_level: subtype curation_status: mapped target_term: id: GO:0006338 label: chromatin remodeling mapping_scope: ok_for_propagation_to_go rationale: In `4.3.11`, the residual chromatin-remodeling subgroup is labeled idiosyncratic Ub binding / other rather than just idiosyncratic. The parent chromatin-remodeling GO term remains the safest propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|persulfide transfer|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|promotes nitric oxide synthesis|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified|CUE subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified|UBA (UBAP1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified|UBA-like subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified|UBA-like (SPATS2) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified|UEV (Type 1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other processes|unspecified|idiosyncratic Ub binding / UBD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers|ADP ribosyltransferase|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers|N-terminal acetylation|UBA (NACA) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers|dipeptidyl peptidase|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|other protein modifiers|histone deacetylase|UBP-associated ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|possible proteasome adaptor|with UBL|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|possible proteasome adaptor|with UBL|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|UIM, idiosyncratic Ub binding / VWA subject_level: subtype curation_status: mapped rationale: This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0005838 label: proteasome regulatory particle mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / MPN subject_level: subtype curation_status: mapped rationale: This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0005838 label: proteasome regulatory particle mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / PRU subject_level: subtype curation_status: mapped rationale: This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0005838 label: proteasome regulatory particle mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / alpha solenoid subject_level: subtype curation_status: mapped rationale: This PN type/subtype is a ubiquitin-binding regulatory-particle subunit bucket. The safe GO target is proteasome regulatory particle. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0005838 label: proteasome regulatory particle mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1|A20 ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with AN1|UBZ (ZFAND2A/B) subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL, STI1|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|proteasome adaptor|with UBL|UBA, STI subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower proteasome-adaptor domain subdivision already covered by the curated parent proteasome-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|AMP-activated Ser/Thr kinases|UBA-like (PRKAA1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|AMP-activated Ser/Thr kinases|UBA-like (PRKAA2) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|GATOR2 complex|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|microtubule-associated Ser/Thr kinases|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|UBA (ACK1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|UBA (BRSK1/2) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|UFM1 binding subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|other Ser/Thr kinase|tandem MIU subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|regulator of IR tyrosine kinase|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|salt-inducible Ser/Thr kinases|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein kinases & regulators|tyrosine kinase|idiosyncratic Ub binding / SH2, SH3 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein phosphatases & regulators|phosphatase regulator|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein phosphatases & regulators|phosphatidylinositol phosphatase|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein phosphatases & regulators|tyrosine phosphatase|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor|CUE subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|ERAD cofactor|idiosyncratic Ub binding / UT3 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|HSP70 cochaperone|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|protein folding & quality control|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|protein quality control|stalled chain recognition|UFM1 binding subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|putative RNA helicase|putative RNA helicase|UBA, RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|related to proteasome adaptor ZFAND5|with AN1|A20 ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity, DUB cofactor|inhibits NF-kappa-B activation|UBAN subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|IKK core complex|UBAN, NEMO-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|Inhibits NF-kappa-B activation|UBAN subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|Inhibits NF-kappa-B activation|UBAN, NEMO-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|TAK1 kinase substrate adaptor|CUE, RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|TBK1 kinase substrate adaptor|UBZ1-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|antigen recognition / GAP & GEF|UIM-like subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|bacterial component sensor|idiosyncratic Ub binding / CARD / type 1 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|modulator of NEMO|UIM, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|receptor in AKT signaling cascade|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|viral dsRNA sensor|idiosyncratic Ub binding / CARD / type 2 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling & immunity|viral nucleic acid sensor|idiosyncratic Ub binding / CARD / type 2 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling|GAP|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|signaling|activates the PI3K/AKT pathway|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|EGFR internalization|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ERphagy|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a selective-autophagy or trafficking subdivision under a UPS binding context. The autophagy context is real, but this node is too indirect for automatic GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-0 complex|UIM, VHS subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-I complex cofactor|UEV (Type 1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-I complex|UBA (UBAP1) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-I complex|UEV (Type 2) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-I complex|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|ESCRT-II complex|idiosyncratic Ub binding / GLUE subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|MYO6 adapter|GAT, VHS subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|Rab effector|MIU, A20 ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|adapter|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|clathrin proximal|GAT, VHS subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|clathrin proximal|UBZ (C2H2) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|clathrin proximal|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|clathrin proximal|idiosyncratic Ub binding / SH3 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|endoprotease (probable)|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|endoprotease|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|endycytosis adapter|idiosyncratic Ub binding / SH3 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|exocytosis|idiosyncratic Ub binding / SH3 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|late endosomes|idiosyncratic Ub binding / alpha solenoid subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|lipophagy|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a selective-autophagy or trafficking subdivision under a UPS binding context. The autophagy context is real, but this node is too indirect for automatic GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|macroautophagy|MIU subject_level: subtype curation_status: no_mapping rationale: Reviewed as a selective-autophagy or trafficking subdivision under a UPS binding context. The autophagy context is real, but this node is too indirect for automatic GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|mitophagy|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a selective-autophagy or trafficking subdivision under a UPS binding context. The autophagy context is real, but this node is too indirect for automatic GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|motor protein / ATPase|MIU subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|phospholipid binding|UBZ (C2H2) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|probable adapter|GAT, VHS subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|selective autophagy|CUE subject_level: subtype curation_status: no_mapping rationale: Reviewed as a selective-autophagy or trafficking subdivision under a UPS binding context. The autophagy context is real, but this node is too indirect for automatic GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|selective autophagy|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a selective-autophagy or trafficking subdivision under a UPS binding context. The autophagy context is real, but this node is too indirect for automatic GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|selective autophagy|UBAN, NEMO-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a selective-autophagy or trafficking subdivision under a UPS binding context. The autophagy context is real, but this node is too indirect for automatic GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|selective autophagy|UBZ1-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed as a selective-autophagy or trafficking subdivision under a UPS binding context. The autophagy context is real, but this node is too indirect for automatic GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|trafficking|transporter regulator|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|DNA binding|CUE (DMA) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation (probable)|CUE (DMA) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation (probable)|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation and repression|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation|idiosyncratic Ub binding / SH2, SH3 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation|idiosyncratic Ub binding / WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|activation|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|coactivation and corepression|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|coactivation and corepression|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|coactivation|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|corepression|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|initiation|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|nuclear hormone receptor|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|regulator|MIU-like subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|regulator|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|repression|RanBP2-type ZnF subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|repression|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|repression|UBA-like (C6orf106) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|transcription|repression|UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|mitochondrial|UBA-like (EF-Ts) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|nascent peptide binding|UBA (NACA) subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|repression|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|ribosome QC & DNA repair|CUE subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|ribosome QC & transcriptional activation|idiosyncratic Ub binding / other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|ribosome maturation|SIM subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL binding|translation|translational upregulation|RWD subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB modulator|WD40 subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB|MPN subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-domain DUB subdivision. The domain architecture is not sufficient for propagation because the subtree includes noncatalytic MPN/UBL-domain cases; active DUB mappings are handled elsewhere. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB|OTU subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-domain DUB subdivision. The domain architecture is not sufficient for propagation because the subtree includes noncatalytic MPN/UBL-domain cases; active DUB mappings are handled elsewhere. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB|USP with external UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-domain DUB subdivision. The domain architecture is not sufficient for propagation because the subtree includes noncatalytic MPN/UBL-domain cases; active DUB mappings are handled elsewhere. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB|USP with internal UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-domain DUB subdivision. The domain architecture is not sufficient for propagation because the subtree includes noncatalytic MPN/UBL-domain cases; active DUB mappings are handled elsewhere. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB|USP with internal UBL & transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-domain DUB subdivision. The domain architecture is not sufficient for propagation because the subtree includes noncatalytic MPN/UBL-domain cases; active DUB mappings are handled elsewhere. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|DUB|USP with internal and external UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower UBL-domain DUB subdivision. The domain architecture is not sufficient for propagation because the subtree includes noncatalytic MPN/UBL-domain cases; active DUB mappings are handled elsewhere. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|CUL1 receptor / F-box subject_level: subtype curation_status: mapped rationale: This PN subtype identifies a UBL-domain F-box/CUL1 receptor role. The safe shared molecular function is ubiquitin-like ligase-substrate adaptor activity rather than catalytic E3 activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:1990756 label: ubiquitin-like ligase-substrate adaptor activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|Cullin adaptor / Elongin B subject_level: subtype curation_status: no_mapping rationale: >- Reviewed as an ELOB-specific UBL-domain cullin-adaptor context. The local ELOB review supports Elongin BC complex membership and ubiquitin protein ligase binding, but explicitly rejects GO:1990756 because substrate recognition is supplied by BC-box, VHL-box, SOCS-box, or related substrate receptors rather than by ELOB itself. references: - proteostasis-workbook-2026 - proteostasis-ms3 - file:human/ELOB/ELOB-ai-review.yaml - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / LUBAC complex subject_level: subtype curation_status: mapped rationale: This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RBR / Parkin subject_level: subtype curation_status: mapped rationale: This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / RAWUL / polycomb subject_level: subtype curation_status: mapped rationale: This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / UHRF subject_level: subtype curation_status: mapped rationale: This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|E3 ligases|RING / other subject_level: subtype curation_status: mapped rationale: This PN node identifies UBL-domain proteins that are E3 ligases. The shared molecular-function target is ubiquitin protein ligase activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|chaperones and related|BAG 6 complex subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|chaperones and related|co-chaperone subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|chaperones and related|similar to UBL4A subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|chaperones and related|tubulin-associated subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|chaperones and related|tubulin-associated, CAP Gly-rich subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|AN1 subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|actin binding subject_level: subtype curation_status: mapped target_term: id: GO:0003779 label: actin binding mapping_scope: ok_for_propagation_to_go rationale: This PN subtype captures non-enzymatic UBL-domain proteins assigned to actin-binding roles. The matching GO activity term is suitable for propagation. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|ankyrin repeat subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|non-enzymatic|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|DNA repair subject_level: subtype curation_status: mapped target_term: id: GO:0006281 label: DNA repair mapping_scope: ok_for_propagation_to_go rationale: This PN subtype groups UBL-domain proteins in nucleic-acid-process contexts that are assigned to DNA repair. Propagation to DNA repair is appropriate. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|double-stranded RNA binding subject_level: subtype curation_status: mapped target_term: id: GO:0003725 label: double-stranded RNA binding mapping_scope: ok_for_propagation_to_go rationale: This PN subtype captures UBL-domain proteins assigned to double-stranded RNA binding. The matching GO molecular-function term is an appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|mRNA splicing subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|pre-mRNA splicing subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|nucleic acid processes|transcriptional modulator subject_level: subtype curation_status: no_mapping rationale: Reviewed as a contextual, regulatory, adaptor, or uncertain UPS bucket. The shared label does not by itself establish a safe gene-level GO propagation. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|other enzymes|aspartic protease subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|other enzymes|enoyl-CoA reductase, transmembrane domain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family, domain, architecture, or residual subdivision. The label is useful for PN taxonomy navigation but is not itself a GO annotation target; any functional assertion should come from a curated parent role or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|other enzymes|kinase subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|other enzymes|proteasome phosphatase subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower ubiquitin-binding domain subdivision already covered by the curated parent ubiquitin-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBA, STI subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower ubiquitin-binding domain subdivision already covered by the curated parent ubiquitin-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBL domain|ubiquitin binding|UBD subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower ubiquitin-binding domain subdivision already covered by the curated parent ubiquitin-binding mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|PUB subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|SEP subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|SEP, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|UBL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|thioredoxin-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|thioredoxin-like, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|Ubiquitin and UBL proteins|UBX domain|VCP adaptors|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a UBX-domain/VCP-adaptor architecture subdivision. The domain label does not by itself establish a direct GO annotation beyond gene-level VCP-adaptor evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|SHP|UT3 subject_level: subtype curation_status: mapped rationale: This PN subtype identifies UFD1 in the canonical VCP-NPL4-UFD1 adaptor complex. The matching GO cellular-component term is VCP-NPL4-UFD1 AAA ATPase complex. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0034098 label: VCP-NPL4-UFD1 AAA ATPase complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX, SHP|SEP subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX, SHP|SEP, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX|UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX|thioredoxin-like subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX|thioredoxin-like, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|UBX|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|VBM|UBL, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|VIM|AN1, UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|VIM|ankyrin repeats subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|VIM|other subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|adaptors|VIM|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a VCP-adaptor motif or architecture subdivision. The label is useful taxonomy but too indirect for direct GO propagation without gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|Josephin|VBM, UIM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated DUB/adaptor subdivision. The VCP context includes both catalytic DUBs and noncatalytic complex members, so no additional direct DUB propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|MPN|UBXL subject_level: subtype curation_status: mapped rationale: This PN subtype identifies NPLOC4 in the VCP-NPL4-UFD1 complex context. The safe GO target is VCP-NPL4-UFD1 AAA ATPase complex, not DUB activity. references: - proteostasis-workbook-2026 - proteostasis-ms3 target_term: id: GO:0034098 label: VCP-NPL4-UFD1 AAA ATPase complex mapping_scope: ok_for_propagation_to_go - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|OTU|UBXL subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated DUB/adaptor subdivision. The VCP context includes both catalytic DUBs and noncatalytic complex members, so no additional direct DUB propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated DUBs|OTU|VBM, A20 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated DUB/adaptor subdivision. The VCP context includes both catalytic DUBs and noncatalytic complex members, so no additional direct DUB propagation is made from this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RBR|PUB, UBA subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated E3 architecture subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RING|TRAC-1 subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated E3 architecture subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RING|VBM & transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated E3 architecture subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|RING|VIM & transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated E3 architecture subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated E3 ligases|UBOX|VBM subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower VCP-associated E3 architecture subdivision already covered by the curated parent E3 mapping. No additional direct GO mapping is needed at this node. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated channel proteins|SHP|transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes|PLA2 activator|PUL subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes|deglycolsylase|PUB subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes|metalloprotease|SHP subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3 - subject_code: Ubiquitin Proteasome System|VCP and associated proteins|associated non-Ub enzymes|serine protease|VBM & transmembrane subject_level: subtype curation_status: no_mapping rationale: Reviewed manually as a UPS source node. No single GO term is appropriate for direct propagation from this PN label without narrower context or gene-level evidence. references: - proteostasis-workbook-2026 - proteostasis-ms3