# PN dossier: CACYBP

- review_batch: proteostasis-batch-2026-06-06
- review_yaml: genes/human/CACYBP/CACYBP-ai-review.yaml
- PN workbook rows: 1

## PN row 1: Cytonuclear proteostasis | Chaperone | HSP90 system | HSP90 cochaperone | CS domain containing
- UniProt: Q9HB71
- In branches: CY
- PN-node mapping records (path + ancestors):
    - [subtype] Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review.
    - [type] Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone
        status=mapped scope=ok_for_propagation_to_go GO=[GO:0051879 Hsp90 protein binding]
        rationale: This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation.
    - [group] Cytonuclear proteostasis|Chaperone|HSP90 system
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations.
    - [class] Cytonuclear proteostasis|Chaperone
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations.
    - [branch] Cytonuclear proteostasis
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a top-level PN branch. This is a systems/taxonomy umbrella, not a direct GO assertion; narrower child curations carry any propagating GO mappings.

## Projected GO annotations (1)
- GO:0051879 Hsp90 protein binding | scope=ok_for_propagation_to_go | goa_status=more_specific_than_existing_goa | from=Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone