# PN dossier: CNPY3

- review_batch: proteostasis-batch-2026-06-07
- review_yaml: genes/human/CNPY3/CNPY3-ai-review.yaml
- PN workbook rows: 1

## PN row 1: ER proteostasis | Chaperone | HSP90 system | HSP90 cochaperone | Folding of TLRs
- UniProt: Q9BT09
- In branches: ER
- PN-node mapping records (path + ancestors):
    - [subtype] ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|Folding of TLRs
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
    - [type] ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone
        status=mapped scope=ok_for_propagation_to_go GO=[GO:0051879 Hsp90 protein binding]
        rationale: This PN type groups ER HSP90/GRP94 cochaperones. Hsp90 protein binding is the shared mechanistic assertion.
    - [group] ER proteostasis|Chaperone|HSP90 system
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
    - [class] ER proteostasis|Chaperone
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
    - [branch] ER proteostasis
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a top-level PN branch. This is a systems/taxonomy umbrella, not a direct GO assertion; narrower child curations carry any propagating GO mappings.

## Projected GO annotations (1)
- GO:0051879 Hsp90 protein binding | scope=ok_for_propagation_to_go | goa_status=more_specific_than_existing_goa | from=ER proteostasis|Chaperone|HSP90 system|HSP90 cochaperone