# PN dossier: CWC27

- review_batch: proteostasis-batch-2026-06-07
- review_yaml: genes/human/CWC27/CWC27-ai-review.yaml
- PN workbook rows: 1

## PN row 1: Cytonuclear proteostasis | Folding enzyme | Peptidyl-prolyl isomerases | Cyclophilin type
- UniProt: Q6UX04
- In branches: CY
- PN-node mapping records (path + ancestors):
    - [type] Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type
        status=mapped scope=ok_for_propagation_to_go GO=[GO:0003755 peptidyl-prolyl cis-trans isomerase activity]
        rationale: This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation.
    - [group] Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases
        status=mapped scope=ok_for_propagation_to_go GO=[GO:0003755 peptidyl-prolyl cis-trans isomerase activity]
        rationale: This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation.
    - [class] Cytonuclear proteostasis|Folding enzyme
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations.
    - [branch] Cytonuclear proteostasis
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a top-level PN branch. This is a systems/taxonomy umbrella, not a direct GO assertion; narrower child curations carry any propagating GO mappings.

## Projected GO annotations (2)
- GO:0003755 peptidyl-prolyl cis-trans isomerase activity | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases
- GO:0003755 peptidyl-prolyl cis-trans isomerase activity | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type