# PN dossier: SEC63

- review_batch: proteostasis-batch-2026-06-11
- review_yaml: genes/human/SEC63/SEC63-ai-review.yaml
- PN workbook rows: 2

## PN row 1: ER proteostasis | Chaperone | HSP70 system | J-domain containing HSP70 cochaperone
- UniProt: Q9UGP8
- In branches: ER
- PN-node mapping records (path + ancestors):
    - [type] ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone
        status=mapped scope=ok_for_propagation_to_go GO=[GO:0030544 Hsp70 protein binding]
        rationale: In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache.
    - [group] ER proteostasis|Chaperone|HSP70 system
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
    - [class] ER proteostasis|Chaperone
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
    - [branch] ER proteostasis
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a top-level PN branch. This is a systems/taxonomy umbrella, not a direct GO assertion; narrower child curations carry any propagating GO mappings.

## PN row 2: ER proteostasis | Protein transport | SEC61 channel complex component
- UniProt: Q9UGP8
- In branches: ER
- PN-node mapping records (path + ancestors):
    - [group] ER proteostasis|Protein transport|SEC61 channel complex component
        status=mapped scope=ok_for_propagation_to_go GO=[GO:0005784 Sec61 translocon complex]
        rationale: This PN group denotes SEC61 translocon components. The GO Sec61 translocon complex term is the direct cellular-component target.
    - [class] ER proteostasis|Protein transport
        status=mapped scope=ok_for_propagation_to_go GO=[GO:0015031 protein transport]
        rationale: The PN ER Protein transport class groups ER-targeting and ER-insertion pathways. GO protein transport is the appropriate propagation target, while the source class remains ER-specific and broader than any single GO transport subtype.
    - [branch] ER proteostasis
        status=no_mapping scope= GO=[]
        rationale: Reviewed as a top-level PN branch. This is a systems/taxonomy umbrella, not a direct GO assertion; narrower child curations carry any propagating GO mappings.

## Projected GO annotations (3)
- GO:0030544 Hsp70 protein binding | scope=ok_for_propagation_to_go | goa_status=more_specific_than_existing_goa | from=ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone
- GO:0015031 protein transport | scope=ok_for_propagation_to_go | goa_status=entailed_by_goa_closure | from=ER proteostasis|Protein transport
- GO:0005784 Sec61 translocon complex | scope=ok_for_propagation_to_go | goa_status=more_specific_than_existing_goa | from=ER proteostasis|Protein transport|SEC61 channel complex component