# PN dossier: SPG11

- review_batch: proteostasis-pr-1217
- review_yaml: genes/human/SPG11/SPG11-ai-review.yaml
- PN workbook rows: 1

## PN row 1: Autophagy-Lysosome Pathway | Autophagic lysosome reformation | Specific function in autophagic lysosome reformation unknown
- UniProt: Q96JI7
- In branches: ALP
- Notes: Important for autophagic-lysosome reformation
- PN references (titles):
    - JCI - Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation
- PN-node mapping records (path + ancestors):
    - [group] Autophagy-Lysosome Pathway|Autophagic lysosome reformation|Specific function in autophagic lysosome reformation unknown
        status=no_mapping scope= GO=[]
        rationale: This PN group explicitly states that the specific role within autophagic lysosome reformation is unknown. That makes GO propagation unsafe until a narrower mechanistic interpretation is available.
    - [class] Autophagy-Lysosome Pathway|Autophagic lysosome reformation
        status=context_only scope=too_broad_to_propagate GO=[GO:0007040 lysosome organization]
        rationale: Autophagic lysosome reformation is the lysosome-regeneration phase that follows autolysosome formation and cargo degradation. As a class, it is better aligned to lysosome organization than to generic autophagy, but the PN members are mechanistically mixed across membrane remodeling, tubulation, product efflux, and unknown late-stage roles, so class-level propagation would still over-annotate.
    - [branch] Autophagy-Lysosome Pathway
        status=no_mapping scope= GO=[]
        rationale: Reviewed as the top-level PN branch. It is a project taxonomy umbrella rather than a direct GO assertion; all propagation must come from manually curated child nodes.