## ABCF2
- **UniProt:** Q9UG63 (review YAML) — dossier lists **A0A090N7X1** (TrEMBL/secondary accession mismatch) · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes` ; **PN-node mapping:** type `other RQC processes`=no_mapping; group `Ribosome-associated QC`=mapped→**GO:0006515 protein quality control for misfolded/incompletely synthesized proteins** (new_to_goa); class/branch context_only.
- **Consistency:** Consistent in conclusions, with a deliberate divergence. Deep research and notes frame ABCF2 as a soluble two-NBD ABCF ATPase (no TMDs, not a transporter; ABC-F family = ribosome-E-site translation factors), with an NFE2L2/cisplatin angle and a putative anti-apoptotic EspF-interaction role. The review accepts ATP binding / ATP hydrolysis / cytosol and removes the membrane/plasma-membrane rows. The review **explicitly declines** the PN-projected GO:0006515 because no ABCF2-specific stalled-ribosome/RQC evidence exists — recording it as an open question instead. PN (RQC bucket) vs review (no RQC process) is a documented, evidence-based divergence, not an error.
- **PN story / NEW pressure:** PN asserts a ribosome-associated QC role not in GOA. The projected GO:0006515 is verified real, but ABCF2-specific RQC evidence is absent; family/context inference alone is insufficient. Conclusion: **PN over-reaches** for ABCF2; correctly held as a suggested question rather than a NEW term. No defensible NEW GO term to add now.
- **Mapping strategy:** The group node `Ribosome-associated QC`→GO:0006515 is sound for bona fide RQC members but should NOT propagate to ABCF2, which sits under the `other RQC processes` (no_mapping) catch-all on family/context grounds only. Treat the GO:0006515 projection as non-propagating for this gene pending direct ribosome-binding/RQC evidence.
- **Evidence alignment:** PN dossier lists no reference titles. Review/notes cite PMID:28112439 (NRF2/cisplatin, cytosolic non-transporter), PMID:17064289 (EspF), PMID:19946888, Reactome R-HSA-9796042 — none establish RQC, so they neither support nor are cited by the PN RQC node. No citation conflict.
- **Verdict:** Consistent (review conservatively rejects the PN RQC projection). **Recommended edits:** [REF] Reconcile UniProt accession — PN dossier/workbook uses A0A090N7X1 but the canonical reviewed entry and review YAML use Q9UG63; update the PN workbook to Q9UG63. [MAP] Keep GO:0006515 non-propagating for ABCF2.