## ABRAXAS1
- **UniProt:** Q6UWZ7 · **batch:** proteostasis-batch-2026-06-03 · **review status:** DRAFT
- **PN placement (2 rows):** `UPS|E3 ubiquitin and UBL ligases|idiosyncratic RING complex|BRCA1-A complex|ubiquitin binding` AND `UPS|Ubiquitin and UBL binding|DNA repair|BRCA1-A complex component|idiosyncratic Ub binding / MPN` ; **PN-node mapping:** type `BRCA1-A complex`=mapped→GO:0070531 (already_in_goa_exact); group `idiosyncratic RING complex`=mapped→GO:0000151 ubiquitin ligase complex (new_to_goa); group `...|DNA repair`=mapped→GO:0006281 DNA repair (entailed_by_goa_closure); class `E3...ligases`/`Ub and UBL binding`=context_only; branch UPS=no_mapping.
- **Consistency:** Consistent on the core: deep-research/notes, review, and PN all converge on ABRAXAS1 as a nuclear BRCA1-A/RAP80 scaffold + polyubiquitin-reader (MPN-like) in DNA damage response. Review accepts GO:0070531 BRCA1-A complex (core), GO:0031593 polyubiquitin-dependent binding, GO:0006302 DSB repair, GO:0045739 positive regulation of DNA repair, GO:0007095 G2 checkpoint. One nuance: the PN group projects GO:0000151 "ubiquitin ligase complex," but the review prefers the more specific GO:0070531 and explicitly calls GO:0000151 "more precise than the PN-projected generic ubiquitin-ligase-complex bucket." Note ABRAXAS1 is a scaffold/DUB-support subunit, **not** an E3 catalytic ligase — so the RING/ligase framing is a placement convenience, not a function claim (review is careful here). No hard contradiction.
- **PN story / NEW pressure:** PN's DNA-repair + ubiquitin-binding + BRCA1-A story is fully captured (GO:0006281 entailed by accepted GO:0006302; GO:0070531 present; GO:0031593 present). All PN-projected terms verified real. Conclusion: **already captured**; the only over-reach is the generic ligase-complex bucket, which the review supersedes with GO:0070531.
- **Mapping strategy:** Group node GO:0000151 should be treated as non-propagating to ABRAXAS1 (review holds the narrower, child term GO:0070531). The DNA-repair group→GO:0006281 is already entailed. Type node GO:0070531 is correct. No new propagation needed.
- **Evidence alignment:** Good overlap. PN reference titles cite PMID:17525340 (row 1) and PMID:19261749 (row 2 signature domain, IPR037518/MPN) — both are central review references (17525340 = ACCEPT-supporting for nucleus/checkpoint/DSB; 19261749 = NBA1/BRCA1-A + polyubiquitin binding). PN and review cite the same anchor papers.
- **Verdict:** Consistent; PN captured (review uses more specific complex term, correctly avoids E3-catalytic over-claim). Status is DRAFT. No substantive edits warranted (optional: finalize DRAFT→COMPLETE after the open RNA-binding and SSA/MMEJ negative-regulation questions are settled).