## ABRAXAS2
- **UniProt:** Q15018 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Ubiquitin Proteasome System|DUBs and UBL demodifiers|BRISC complex|noncatalytic|JAMM / MPN / ubiquitin binding` (row 1) and `...|Ubiquitin and UBL binding|DNA repair|BRISC complex component|...` (row 2) ; **PN-node mapping:** group/type `BRISC complex`=mapped→**GO:0070552 BRISC complex** (already_in_goa_exact); group `...|DNA repair`=mapped→**GO:0006281 DNA repair** (new_to_goa); class `Ubiquitin and UBL binding`=context_only (too_broad).
- **Consistency:** Deep-research notes, review YAML, and PN-node BRISC mapping all agree ABRAXAS2 (=ABRO1/FAM175B) is a **noncatalytic BRISC scaffold/adaptor**, not a catalytic JAMM DUB. **Partial contradiction at the DNA-repair node:** the PN row-2 group projects broad GO:0006281 DNA repair, but the review and notes explicitly argue ABRO1 lacks the BRCA1-interacting motif and does NOT join BRCA1-A/DNA-repair sites (PMID:21282113), so direct DNA-repair propagation is rejected.
- **PN story / NEW pressure:** BRISC complex membership is already captured (GO:0070552, IDA/IPI/NAS in GOA). The DNA-repair claim over-reaches for this paralog. The review instead adds well-supported NEW terms the PN node does not surface: **GO:0043517** positive regulation of DNA damage response, signal transduction by p53 class mediator (OLS-verified real; PMID:25283148, ABRO1 stabilizes p53 via USP7) and **GO:0060340** positive regulation of type I interferon-mediated signaling (PMID:24075985/31142841, BRISC-SHMT2/IFNAR1), plus NuMA spindle-assembly terms. Conclusion: BRISC = already captured; DNA repair = PN over-reaches; p53-DDR signaling = legitimate ADD already done in review.
- **Mapping strategy:** The BRISC node mapping is correct and stable. The `...|DNA repair` group node should **not** propagate GO:0006281 to ABRAXAS2 — the p53-class mediator is a paralog-specific signaling role, not direct repair. This mirrors the precedent of suppressing an over-broad projected term for a specific gene.
- **Evidence alignment:** PN row references (PMID:36473924, 19261749) overlap the review's BRISC/polyubiquitin-binding evidence (PMID:19261749 used, marked over-annotated as BRCA1-A-specific). Review extends far beyond PN refs (PMID:21282113, 20656690, 24075985, 25283148, 26195665, 31142841, 31253574) — divergence is enrichment, not conflict.
- **Verdict:** Consistent on BRISC; PN DNA-repair projection over-reaches and is correctly declined; review's p53-DDR/IFN NEW terms are sound. **Recommended edits:** [MAP] Do not project GO:0006281 DNA repair to ABRAXAS2; the supported DNA-damage role is GO:0043517 (p53-class DDR signaling), already added in the review.