## ABTB2
- **UniProt:** Q8N961 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Ubiquitin Proteasome System|E3 ubiquitin and UBL ligases|Cul3 substrate receptor|BTB-BACK, variant|ankyrin` ; **PN-node mapping:** group `Cul3 substrate receptor`=mapped→**GO:1990756 ubiquitin-like ligase-substrate adaptor activity** (new_to_goa); class `E3 ubiquitin and UBL ligases`=context_only (too_broad→GO:0061630); subtype/type/branch=no_mapping.
- **Consistency:** Deep-research (manual fallback), notes, review YAML, and the PN Cul3-adaptor mapping are mutually consistent. All converge on ABTB2 as a **BTB/POZ substrate-adaptor** that binds CUL3 and promotes TRAP1 ubiquitin-dependent degradation (PMID:41322190). No contradictions. The review prudently treats older BPOZ-2 papers as nomenclature-ambiguous with ABTB1 and excludes them as primary evidence.
- **PN story / NEW pressure:** PN asserts adaptor activity not in the original GOA (which had only GO:0046982 heterodimerization IEA, GO:0005515 protein binding IPI, GO:0005654 nucleoplasm). The review **adds** the PN-projected **GO:1990756** (OLS-verified real) as a direct IDA NEW annotation, supported by ABTB2-TRAP1 co-IP, TRAP1 ubiquitination/degradation, and reported ABTB2-cullin-3 interaction, plus companion **GO:0016567** protein ubiquitination. This is gene-specific support, not domain-only projection. Conclusion: legitimate ADD, executed in the review.
- **Mapping strategy:** This gene **strengthens** the Cul3-substrate-receptor group mapping with direct experimental evidence (unlike its paralog ABTB3). The group-level GO:1990756 scope is appropriate (adaptor activity, not catalytic E3); the review correctly avoids GO:0061630 ubiquitin protein ligase activity. No change needed.
- **Evidence alignment:** PN row references (PMID:15071497, 23912815 — generic Cul3/BTB reviews) do NOT overlap the review's primary evidence (PMID:41322190, the 2025 PDAC study); the review rests on stronger gene-specific data than the PN row's domain-review citations. Generic 14-3-3 interactome (PMID:36931259) shared but marked over-annotated.
- **Verdict:** Fully consistent; PN GO:1990756 projection validated by direct evidence and correctly added as NEW. **Recommended edits:** none (mapping and review aligned).