## ADRB2
- **UniProt:** P07550 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Autophagy-Lysosome Pathway|Autophagy substrate selection|Marking substrates for selective autophagy|Lipophagy|Upstream lipophagy signaling` ; **PN-node mapping:** type `Lipophagy`=mapped→**GO:0061724 lipophagy** (scope=ok_for_propagation; goa_status=supported_by_goa_regulation); group/class/branch=no_mapping; subtype `Upstream lipophagy signaling`=no_mapping.
- **Consistency:** **CONTRADICTION (PN projection rejected by review).** PN node label itself says "Upstream lipophagy **signaling**," yet the type-node projects direct **GO:0061724 lipophagy**. The review, notes, and Falcon deep research all agree ADRB2 is the **beta-2 adrenergic GPCR** acting as an **upstream signal** for adipocyte lipophagy; the direct lipid-droplet/autolysosome machinery in the source paper is **RAB7**, not ADRB2 (PMID:23708524). The review keeps existing GO:1904504 positive regulation of lipophagy (IDA, in GOA) and declines direct lipophagy.
- **PN story / NEW pressure:** PN pressures a direct-process term (GO:0061724, OLS-verified real) onto an upstream signaling gene. The regulatory role is **already captured** in GOA (GO:1904504 positive regulation of lipophagy + GO:1905168 positive regulation of autophagosome maturation, both KEEP_AS_NON_CORE). No NEW direct term is defensible; the core function is GPCR/catecholamine signaling. Conclusion: PN over-reaches (regulation→direct process upgrade); already captured at the regulation level.
- **Mapping strategy:** Direct precedent of **TOMM20/HSPA8/RAB7A rejected as broader/mis-leveled.** Here the PN-projected GO:0061724 is mis-leveled in the opposite direction — it asserts the direct process for a gene that only regulates it upstream. GO:0061724 should **not** propagate to ADRB2; the safe target is the regulation term already in GOA. The review even flags this as an open question (line ~2522: "Should PN projection for ADRB2 remain at GO:1904504 ... rather than direct GO:0061724").
- **Evidence alignment:** PN reference (the tandfonline RAB7/autolysosomal-lipid-degradation article = PMID:23708524) is the **same paper** the review uses — and that paper's own data assign the direct machinery to RAB7, supporting the review's downgrade. No citation divergence; interpretation diverges (direct vs upstream).
- **Verdict:** PN direct-lipophagy projection over-reaches; review correctly retains positive-regulation-of-lipophagy and declines GO:0061724 (RAB7 is the direct factor). **Recommended edits:** [MAP] Keep ADRB2 mapping at GO:1904504 positive regulation of lipophagy; do not propagate direct GO:0061724 lipophagy.