## ADRM1
- **UniProt:** Q16186 (Rpn13) · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `UPS|Proteasome and associated proteins|proteasome regulatory particle subunit|base, nonATPase|PRU, DEUBAD` (row 1) and `UPS|Ubiquitin and UBL binding|proteasomal subunits|regulatory particle|idiosyncratic Ub binding / PRU` (row 2) ; **PN-node mapping:** type `base, nonATPase`=mapped→**GO:0008540 base subcomplex** (more_specific_than_existing_goa); group `regulatory particle subunit`=mapped→**GO:0005838 regulatory particle**; group `proteasomal subunits`=mapped→**GO:0000502 proteasome complex** (already_in_goa_exact); ub-binding classes=context_only.
- **Consistency:** Deep research (manual), notes, review YAML, and all PN-node mappings are mutually consistent. ADRM1/Rpn13 is a 19S regulatory-particle ubiquitin receptor (Pru domain) that binds Rpn2/PSMD1 and recruits/activates the UCHL5/UCH37 DUB (PMID:16990800, 17139257, 18497817, 20471946, 29636472). No contradictions.
- **PN story / NEW pressure:** PN's key non-trivial assertion is base- (not lid-) subcomplex membership (GO:0008540, OLS-verified real). GOA carried an IBA GO:0008541 **lid** subcomplex annotation; the review **MODIFIES** it to GO:0008540 base subcomplex, citing Rpn13/Rpn10 as base ubiquitin receptors (PMID:29636472, 33729481) — exactly executing the PN projection. Other projected terms (GO:0000502, GO:0005838) already captured/entailed. Review also adds specific MFs beyond PN (GO:0035800 deubiquitinase activator via MODIFY of GO:0061133; GO:0043130 ubiquitin binding; GO:0070628 proteasome binding; GO:1990381 ubiquitin-specific protease binding). Conclusion: PN base-subcomplex correction = legitimate ADD/MODIFY, executed; rest already captured.
- **Mapping strategy:** This gene **confirms** the base-subcomplex mapping (lid→base is a genuine GOA correction, not over-reach). All PN scopes are correctly leveled (CC membership terms, no over-broad propagation). No change needed.
- **Evidence alignment:** PN references (PMID:19145068, 19489727, 18497827, 32160516) overlap the review's Rpn13/Pru/DEUBAD evidence base; the review additionally uses the foundational identification and structural papers (16990800, 17139257, 18497817, 20471946, 29636472, 33729481). Strong overlap, review enriched — no conflict.
- **Verdict:** Fully consistent; PN's lid→base correction and regulatory-particle/proteasome-complex mappings all validated and executed in the review. **Recommended edits:** none (mapping and review aligned).