## AFG3L2
- **UniProt:** Q9Y4W6 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Mitochondrial proteostasis|Organelle-specific protein degradation|Matrix protease` ; **PN-node mapping:** group `mapped` ok_for_propagation GO:0005759 mitochondrial matrix; class `mapped` GO:0035694 mitochondrial protein catabolic process; branch `no_mapping`.
- **Consistency:** Deep research (falcon), review YAML, and PN annotation agree on the core picture: AFG3L2 is the m-AAA inner-membrane AAA+/M41 zinc metalloprotease performing mitochondrial protein QC, processing (MRPL32), and regulated degradation (EMRE, SLC25A39/45, PINK1, TMBIM5). One deliberate, well-flagged divergence: the PN group projects GO:0005759 mitochondrial matrix as the localization target, but the review rejects this (AFG3L2 is an integral inner-membrane protein with matrix-facing catalytic domains) and keeps GO:0005743 mitochondrial inner membrane. The NEW row's `reason` explicitly states the matrix projection is not accepted. No contradiction beyond this intentional correction.
- **PN story / NEW pressure:** PN class target GO:0035694 mitochondrial protein catabolic process (verified real, non-obsolete) is added as a NEW (IC) annotation and used to MODIFY the generic GO:0006508 proteolysis / GO:0030163 protein catabolic process rows. Defensible and conservative — directly supported by SLC25A39 degradation papers (PMID:37917749, 38157846). Verdict: ADD (already implemented in review).
- **Mapping strategy:** Gene refines, does not change, the node. The class→GO:0035694 mapping is correct and adopted. The group→GO:0005759 matrix mapping is too specific/wrong-compartment for AFG3L2; review's rejection is sound (matrix-facing topology ≠ matrix residence).
- **Evidence alignment:** PN dossier carries no reference titles; review is densely evidenced (PMID:31327635, 29932645, 19748354, 27642048, 28396416, 37917749, 38157846, 41075794). PN projection TSV is cited as supporting file for GO:0035694. No PMID-level conflicts.
- **Verdict:** Consistent; PN GO:0035694 correctly adopted as NEW; PN matrix (GO:0005759) projection correctly overruled at gene level. **Recommended edits:** none required. Optional [MAP]: flag mitochondrial-proteostasis "Matrix protease" group GO:0005759 as too specific for inner-membrane matrix-facing proteases (consider GO:0005743 or no_mapping).