## AGK
- **UniProt:** Q53H12 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Mitochondrial proteostasis|Protein transport|Inner membrane import|TIMM22 complex` ; **PN-node mapping:** type (TIMM22) `mapped` GO:0042721 TIM22 complex (already_in_goa_exact); group (inner-membrane import) `context_only` too_broad GO:0044743; class (Protein transport) `mapped` GO:0015031 protein transport (new_to_goa); branch `no_mapping`.
- **Consistency:** Deep research notes (falcon failed; manual fallback), review, and PN agree on AGK's dual role: mitochondrial acylglycerol/diacylglycerol kinase (LPA/PA) plus kinase-independent TIM22-complex subunit supporting carrier-protein import. No contradictions. The review actively removes mis-seeded ceramide/sphingosine-kinase and plasma-membrane/BRAF-fusion-cytosol annotations — independent of PN, and consistent with PN's mitochondrial framing.
- **PN story / NEW pressure:** PN class projects GO:0015031 protein transport as new-to-GOA. The review instead uses the more specific, directly-supported GO:0045039 protein insertion into mitochondrial inner membrane (IDA, PMID:28712724/28712726/32901109) and notes the strongest PN-relevant role is the TIM22 import-complex role "not a generic protein-transport assertion." GO:0042721 TIM22 complex is already in GOA (3 rows confirmed). Verdict: PN protein-transport role already captured by a narrower term; broad GO:0015031 not needed.
- **Mapping strategy:** Gene does not change the node. The TIMM22-type GO:0042721 mapping is correct and adopted. The class-level GO:0015031 protein transport projection is broader than the review's GO:0045039 — same broader-rejected pattern as TOMM20/HSPA8/RAB7A; gene-level narrower term is preferred. PN's own group node is already `too_broad_to_propagate`, consistent with this.
- **Evidence alignment:** PN dossier lists no reference titles. Review evidence overlaps PN's mitochondrial-import framing via PMID:28712724, 28712726, 32901109 (TIM22), 15939762 (lipid kinase). PN projection TSV cited for GO:0045039 context. No PMID conflicts.
- **Verdict:** Consistent; PN TIM22 (GO:0042721) adopted; PN class GO:0015031 protein transport too broad — review's GO:0045039 is the correct narrower call. **Recommended edits:** none required. Optional [MAP]: confirm class-level GO:0015031 stays gene-gated in favor of compartment-specific insertion/import terms.