## AHCTF1
- **UniProt:** Q8WYP5 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Nuclear proteostasis|Protein transport|Nuclear pore complex` ; **PN-node mapping:** group (NPC) `mapped` ok_for_propagation GO:0005643 nuclear pore (already_in_goa_exact); class (Protein transport) `mapped` GO:0015031 protein transport (new_to_goa); branch `no_mapping`.
- **Consistency:** Deep research (falcon), review, and PN agree AHCTF1/ELYS is a chromatin-binding nucleoporin that seeds post-mitotic NPC reassembly by recruiting the Nup107-160/Y-complex; also has kinetochore/cytokinesis roles. No contradictions. The review trims ~17 mis-seeded Reactome cytosol rows (mitotic-checkpoint/NPC-assembly pathway context, not AHCTF1 localization) — orthogonal to and compatible with PN's NPC framing.
- **PN story / NEW pressure:** PN group GO:0005643 nuclear pore is already in GOA (confirmed: IEA/NAS/IDA rows) and accepted. PN class projects GO:0015031 protein transport as new-to-GOA, but the review reframes the BP from generic transport to GO:0051292 nuclear pore complex assembly (MODIFY of GO:0006913 nucleocytoplasmic transport; already an IMP annotation) and adds a NEW MF GO:0003682 chromatin binding (IDA, PMID:27341616). Verdict: PN nuclear-pore captured; PN "protein transport" over-reaches — AHCTF1 is an assembly factor, not a transport carrier. The review even questions whether AHCTF1 belongs in a proteostasis source list at all (only via broad NPC/transport projection).
- **Mapping strategy:** Gene does not change the node; it argues against the class-level GO:0015031 projection. AHCTF1 builds the pore rather than transporting cargo, so generic protein transport is biologically the wrong BP — clearer mis-projection than the TOMM20/HSPA8/RAB7A "merely broader" cases.
- **Evidence alignment:** PN dossier lists no reference titles. Review anchors on PMID:17098863 (ELYS dual nucleoporin/kinetochore), 27341616 (conserved MEL-28/ELYS domains, chromatin binding), 24315095/27016207 (NPC scaffold), Reactome:R-HSA-9615901 (chromatin+Nup107-160 seeding). No PMID conflicts.
- **Verdict:** Consistent; PN nuclear pore (GO:0005643) adopted; PN class GO:0015031 protein transport over-reaches for an NPC-assembly factor — review's GO:0051292 + GO:0003682 are the correct calls. **Recommended edits:** none required. [MAP]: flag class-level GO:0015031 for the Nuclear proteostasis|Protein transport node as too broad for structural NPC-assembly factors; consider gene-gating. [WB]: optionally reconsider AHCTF1's inclusion in the PN source list (assembly factor, weak proteostasis link).