## AIP
- **UniProt:** O00170 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** two rows — `Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and PPIase domain containing` and `Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type` ; **PN-node mapping:** type (cochaperone) `mapped` GO:0031072 heat shock protein binding; PPIase type/group `mapped` GO:0003755 peptidyl-prolyl cis-trans isomerase activity (already_in_goa_exact); subtype/class/branch `no_mapping`.
- **Consistency:** Deep research (falcon), review, and PN node mapping agree AIP is a cytosolic TPR co-chaperone/scaffold in the HSP90-AHR complex with FKBP-fold. Sharp, intentional divergence on the PPIase projection: PN type/group map AIP to GO:0003755, but the review REMOVEs both GO:0003755 rows (IEA and IDA/PMID:14557246) because PMID:19375531 shows the FKBP-like domain is catalytically inactive. The review explicitly states the family-level PN PPIase projection "should not be propagated for AIP." Well-reasoned, not a defect.
- **PN story / NEW pressure:** PN cochaperone target GO:0031072 heat shock protein binding is broad; the review instead adopts the more specific GO:0051879 Hsp90 protein binding (replacing obsoleting GO:0051082 and as a core_function). No NEW GO term needed — co-chaperone function already captured. Verdict: already captured (with a more specific term than PN proposes).
- **Mapping strategy:** Gene does not change the node, but is a counterexample to the FKBP/PPIase-type GO:0003755 projection (mixed PPIase/PPIase-like bucket; subtype already correctly `no_mapping`). The GO:0031072 cochaperone mapping is defensible at family level but over-broad for AIP specifically.
- **Evidence alignment:** PN dossier lists no reference titles; review verifies PPIase-inactivity via PMID:19375531 and HSP90/TPR binding via PMID:19375531/28634279, plus cryo-EM DOI:10.1038/s41467-022-34773-w. Many generic protein-binding IPI rows held UNDECIDED. No citation conflicts.
- **Verdict:** Consistent; PN PPIase (GO:0003755) projection correctly overruled with direct biochemical evidence; cochaperone role captured more specifically as GO:0051879. **Recommended edits:** none required. Optional [MAP]: note FKBP-type PPIase group GO:0003755 over-projects to catalytically-dead members (AIP); flag for gene-level gating.