## AKIRIN1
- **UniProt:** Q9H9L7 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin` ; **PN-node mapping:** Akirin *type* no_mapping; *group* (adaptors) mapped→GO:0070628 (proteasome binding, propagate); class context_only→GO:0000502. Projection: **GO:0070628 new_to_goa**.
- **Consistency:** Contradiction between PN projection and review. PN projects proteasome binding (GO:0070628) onto AKIRIN1 via the shared "Akirin" adaptor bucket. The review and deep research (falcon) argue this is **paralog over-transfer**: the proteasome-import adaptor activity is established for AKIRIN2 (PMID:34711951), not AKIRIN1. UniProt and the review explicitly contrast AKIRIN1 (nuclear transcriptional cofactor, promyogenic) with AKIRIN2's proteasome role. The review does NOT adopt GO:0070628 and flags the projection as unsupported.
- **PN story / NEW pressure:** PN asserts proteasome binding not in GOA. GO:0070628 is a real term and genuinely absent from AKIRIN1 GOA, but there is **no AKIRIN1-specific primary evidence** for it; the only direct binding datum is an IntAct GOPC interaction (review MODIFY→GO:0044877 protein-containing complex binding). Verdict: over-reaches — this is family/paralog propagation (PLI-like: the wrong Akirin paralog), not a defensible ADD for AKIRIN1.
- **Mapping strategy:** The Akirin *type* node groups AKIRIN1+AKIRIN2; the parent "adaptors" group→GO:0070628 propagation is correct for AKIRIN2 but wrong for AKIRIN1. The mapping should split the Akirin type so proteasome binding propagates only to AKIRIN2, or mark AKIRIN1 as a no_mapping/excluded member.
- **Evidence alignment:** Dossier lists no PN reference titles for AKIRIN1. Review cites PMID:18066067 (conserved nuclear cofactor), PMID:23516508 (promyogenic), and pointedly PMID:34711951 as a **negative contrast** (AKIRIN2-specific). Divergence is in interpretation, not citation.
- **Verdict:** PN GO:0070628 projection over-reaches — paralog mis-transfer from AKIRIN2; review correctly withholds.
- **Recommended edits:** [MAP] Split the `adaptors|Akirin` type so GO:0070628 proteasome binding propagates to AKIRIN2 only; mark AKIRIN1 as no_mapping (nuclear transcription cofactor, no proteasome-binding evidence).