## AKIRIN2
- **UniProt:** Q53H80 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `Ubiquitin Proteasome System|Proteasome and associated proteins|adaptors|Akirin` ; **PN-node mapping:** Akirin *type* no_mapping; *group* (adaptors) mapped→GO:0070628 (proteasome binding, propagate); class context_only→GO:0000502. Projection: **GO:0070628 new_to_goa**.
- **Consistency:** Fully consistent across all four layers. Deep research (falcon), review, PN annotation, and PN-node mapping all agree AKIRIN2 is the proteasome-import adaptor: homodimers bridge assembled 20S proteasomes to importin IPO9 for nuclear import (PMID:34711951). Review adopts the PN projection as **action NEW GO:0070628**, plus GO:0030674 adaptor activity, GO:0006606, GO:0031144, GO:0071630 — a coherent proteostasis core.
- **PN story / NEW pressure:** PN asserts proteasome binding not in GOA; GOA confirms only GO:0031144 and GO:0071630 are present (GO:0070628 genuinely new_to_goa). GO:0070628 verified real and **directly supported** by primary biochemistry. Verdict: ADD — well justified; this is the model case the Akirin bucket was built for.
- **Mapping strategy:** No change to the node for AKIRIN2; the adaptors→GO:0070628 mapping is exactly right here. (The only caveat is shared with AKIRIN1: the Akirin *type* lumps both paralogs, and the proteasome activity is AKIRIN2-specific — see AKIRIN1 recommendation to split. AKIRIN2 keeps the mapping.) PN-projected GO:0070628 is appropriately specific (neither broader nor narrower than the review's core MF).
- **Evidence alignment:** Strong overlap. PN reference 34711951 = the central review reference PMID:34711951. Review additionally MARK_AS_OVER_ANNOTATED the many high-throughput protein-binding rows (PMID:16189514, 28514442, 31515488, 32296183, 33961781, 40205054) — consistent triage, no conflict.
- **Verdict:** Consistent and well-supported; GO:0070628 ADD confirmed (already realized as NEW in review).
- **Recommended edits:** None for AKIRIN2 (mapping and review aligned). (Cross-ref: the AKIRIN1 split recommendation keeps GO:0070628 on AKIRIN2 only.)