## ANAPC2

- **UniProt:** Q9UJX6 (APC2) · **batch:** proteostasis-batch-2026-06-03 (Falcon DR 2026-06-07) · **review status:** COMPLETE
- **PN placement:** 3 rows, UPS. (1) `…Cullin|degenerate, APC sununit`; (2) `…idiosyncratic RING complex|Anaphase Promoting Complex|catalytic / core`; (3) `…Ubiquitin and UBL binding|E3 ligase complex component|APC / catalytic subunit`. **PN-node mapping:** Cullin group=`mapped`→GO:0160072 scaffold activity (new_to_goa); APC type=`mapped`→GO:0005680 anaphase-promoting complex (already_in_goa_exact); RING-complex/E3-component groups=`mapped`→GO:0000151 ubiquitin ligase complex (entailed_by_goa_closure).
- **Consistency:** Fully consistent. DR ↔ notes ↔ YAML ↔ PN all converge: ANAPC2 is the cullin-like scaffold subunit of the APC/C catalytic module (Apc2-Apc11). No contradiction.
- **PN story / NEW pressure:** PN projects three terms; review handles each correctly. GO:0005680 already_in_goa → ACCEPT (IBA). GO:0000151 entailed via GO:0005680/GO:0031461 → correctly NOT added. **GO:0160072 ubiquitin ligase complex scaffold activity (verified real, new_to_goa): review ADDS as `action: NEW`** (IC, PMID:26083744) only after gene-level scrutiny of structural literature (Apc2-Apc11 catalytic module; PMID:11739784 minimal module, 16364912). Defensible — APC2 is a degenerate cullin scaffold. Conclude: ADD (GO:0160072), others already captured/entailed.
- **Mapping strategy:** ANAPC2 supports, rather than changes, the node mappings. The Cullin-group scaffold projection is precisely the term gene-level review accepts; APC and ligase-complex memberships are appropriately already-in/entailed. Scopes (ok_for_propagation) correct; no broader/narrower mismatch.
- **Evidence alignment:** PN cites PMID:16763193, 21107322, 29167309, 27259151, 31350353. Review uses overlapping structural set (16364912, 26083744, 11739784, 18485873, 29033132) plus DR additions PMID:37735619 (TR cryo-EM E2 docking), 39567505 (APC2 Zn module), 36548081 (DEPTOR substrate) as statement-only. Good overlap on APC/C catalytic-module structure; review enriches with newer cryo-EM.
- **Verdict:** Consistent; GO:0160072 NEW warranted and matches PN (new_to_goa). GO:0005680 ACCEPT, GO:0000151 correctly entailed. No over-reach.
- **Recommended edits:** none to ANAPC2-ai-review.yaml; PN mappings sound as-is.