## ARL8B

- **UniProt:** Q9NVJ2 · **batch:** proteostasis-batch-2026-06-03 (Falcon DR 2026-06-07) · **review status:** COMPLETE
- **PN placement:** 2 rows, ALP (identical structure to ARL8A). (1) `…Localization of the autophagosome|Movement of autophagosomes along microtubules|HOPS-BORC complex bridging`; (2) `…Autophagosome-lysosome docking|HOPS-BORC interaction mediator`. **PN-node mapping:** localization group + movement/bridging leaves=`mapped`→GO:0061906 autophagosome localization (new_to_goa); docking nodes=`context_only`→GO:0061909; class=`context_only`→GO:0016236.
- **Consistency:** Consistent, with deliberate PN-vs-review divergence on GO:0061906. DR ↔ notes ↔ YAML agree: ARL8B is the better-characterized paralog — lysosomal small GTPase recruiting SKIP/PLEKHM2-kinesin (anterograde), HOPS/VPS41 (fusion), RUFY3/4 and DENND6A/Rab34/RILP (retrograde).
- **PN story / NEW pressure:** PN's projected term **GO:0061906 autophagosome localization (verified real, new_to_goa): review DECLINES** — ARL8B drives lysosome positioning and autophagosome-lysosome fusion/cargo delivery, not direct positioning of autophagosomes as cargo. The autophagy role IS already captured by the existing **GO:0061909 autophagosome-lysosome fusion (IMP, PMID:28325809) which the review ACCEPTs.** So the genuine autophagy story is already in GOA via fusion, and GO:0061906 over-reaches. Conclude: already-captured (fusion) + GO:0061906 not supported.
- **Mapping strategy:** Same as ARL8A — mapping flagged `manual_gene_level_review_required`; gene-level review declines GO:0061906 projection. Right process family, wrong cargo organelle; shared target should remain lysosome localization (GO:0032418) / existing fusion term.
- **Evidence alignment:** PN cites the same three titles as ARL8A (Arl8 review; BORC; RUFY3/4=PMID:35314674). Review anchors PMID:16537643, 25898167 (BORC), 22172677 (SKIP/kinesin), 21802320 (VPS41/HOPS), 28325809 (PLEKHM1/fusion), 35314674 (RUFY3/4); DR added PMID:38296963 (DENND6A), 38128568 (BORCS8). **REF ISSUE flagged in review:** seeded GO:0007059 chromosome segregation cites PMID:14871887 (a Drosophila Topors paper, wrong gene) — review retains term as non-core (supported by GIE PMID:15331635) and flags the mismatch with a reference_review + suggested correction.
- **Verdict:** Consistent; PN GO:0061906 over-reaches; autophagy role already captured via GO:0061909 (ACCEPTed). REF mismatch (PMID:14871887) correctly flagged, not removed.
- **Recommended edits:** none to ARL8B-ai-review.yaml (it already flags both issues). [MAP] do not propagate GO:0061906 to ARL8B (autophagy role captured by GO:0061909). [REF] PN/curators: correct GO:0007059 origin reference PMID:14871887 → PMID:15331635 (GIE/ARL8 study).