## ASCC3
- **UniProt:** Q8N3C0 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE (Falcon DR present)
- **PN placement:** `Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue` ; **PN-node mapping:** type=mapped/ok GO:0072344 (already_in_goa_exact); group=mapped/ok GO:0006515 (new_to_goa); class/branch context_only.
- **Consistency:** Fully consistent. Deep research, notes, and review YAML agree ASCC3 has two cores: (1) nuclear ATP-dependent 3'-5' DNA helicase of the ASCC-ALKBH3 dealkylation-repair complex; (2) cytosolic hRQT/RQT2 ATPase that splits K63-ubiquitinated collided ribosomes. The PN RQC placement matches the cytosolic role exactly. GO:0072344 is present in GOA and ACCEPTed in-review.
- **PN story / NEW pressure:** PN's ribosomal-rescue assertion is genuinely captured: review already holds GO:0072344, GO:0032790 (ribosome disassembly), GO:1990116, GO:0180022 (RQC-trigger complex), all ACCEPT. The group-level projection GO:0006515 (broad protein QC) is new_to_goa but the notes correctly decline it as **redundant/less informative** than the existing specific RQC terms. **Conclude: already captured** (specific terms preferred over the broad PN ancestor). No NEW term needed.
- **Mapping strategy:** ASCC3 is the strongest driver/anchor for this RQC node — direct experimental evidence for splitting collided ribosomes. The exact-match GO:0072344 is well-justified. The broader GO:0006515 group mapping is the TOMM20/HSPA8/RAB7A-style "broader than review" case and should NOT be projected to ASCC3 (specific terms already exist). Node status/scope fine; ASCC3 needs no change.
- **Evidence alignment:** PN row has no reference titles. Review RQC evidence (PMID:32099016 hRQT; PMID:32579943 disassembly; PMID:36302773 K63-uS10) is exactly on-point; DNA-repair arm (PMID:22055184, PMID:29144457) aligns with the nuclear role. No citation conflicts.
- **Verdict:** Consistent and well-supported; PN story already captured by specific GO terms. Broad GO:0006515 projection correctly declined. No edits warranted.