## ATAD1
- **UniProt:** Q8NBU5 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE (Falcon DR present)
- **PN placement:** `Mitochondrial proteostasis|Organelle-specific protein degradation|mitoCPR pathway` ; **PN-node mapping:** group(mitoCPR)=no_mapping; class(Organelle-specific protein degradation)=mapped/ok GO:0035694 (mitochondrial protein catabolic process, new_to_goa); branch=no_mapping.
- **Consistency:** Consistent. Deep research, notes, review YAML agree ATAD1/Msp1 is a hexameric OMM AAA+ extractase/dislocase that removes mislocalized tail-anchored proteins (PEX26/GOS28) and the BH3-only protein BIM, for rerouting or degradation. Review core = GO:0140567 (membrane protein dislocase) + GO:0140570 (extraction of mislocalized protein from mitochondrial OM). The PN class is degradation-centric; ATAD1's sharper mechanism is extraction, but degradation is a real downstream outcome.
- **PN story / NEW pressure:** PN projects GO:0035694 (mitochondrial protein catabolic process), absent from ATAD1 GOA. The review **accepted it as NEW (TAS)** — notably GO:0140570 is NOT a subclass of GO:0035694 (verified via OLS: GO:0140570 sits under establishment-of-protein-localization, not catabolic process), so the two are orthogonal, not redundant. Adding GO:0035694 is defensible (degradation outcome supported by PMID:24843043) though broader/less mechanistic than GO:0140570. **Conclude: ADD already done in-review** (accepted NEW); both terms real and complementary.
- **Mapping strategy:** ATAD1 mildly supports the class mapping. GO:0035694 is broader than the gene's specific GO:0140570 but, unlike TOMM20-type rejections, it is a distinct degradation axis the review judged worth a conservative NEW. mitoCPR leaf no_mapping is appropriate (human mitoCPR poorly defined). Node status/scope fine.
- **Evidence alignment:** PN row carries no reference titles. Review anchors on PMID:24843043 (extraction/degradation of TA proteins) plus new human primaries (PMID:36409067 BIM; PMID:35550246 cryo-EM) — all reinforce the dislocase core. No citation conflicts.
- **Verdict:** Consistent; PN GO:0035694 is real, complementary to GO:0140570, and already added as NEW. No edits warranted.