## ATAD3A
- **UniProt:** Q9NVI7 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `ALP|Autophagy substrate selection|Marking substrates for selective autophagy|Mitophagy|PINK/PRKN pathway` ; **PN-node mapping:** PINK/PRKN subtype `no_mapping`; Mitophagy type `mapped`, `ok_for_propagation_to_go` → GO:0000423 mitophagy (new_to_goa).
- **Consistency:** Consistent, with a deliberate, well-documented divergence from the projection. Deep research (manual synthesis), review YAML, and notes all describe ATAD3A as a mitochondrial inner-membrane AAA+ ATPase for network/nucleoid/mtDNA organization and mitochondrial translation, with secondary stress signaling (PERK, HRI/ISR). The PN mitophagy projection is explicitly evaluated and rejected in notes ("I did not add GO:0000423 mitophagy"). No internal contradiction.
- **PN story / NEW pressure:** PN asserts ATAD3A in mitophagy (GO:0000423, real term). PN Notes base this on a mouse Atad3a/Pink1 study (Nat Immunology) where Atad3a *suppresses* mitophagy. The review correctly declined to ADD mitophagy: human evidence shows ATAD3A normally restrains PINK1 accumulation, so a positive "involved_in mitophagy" annotation would mis-state directionality, and no direct cargo-marking/receptor role is shown. Verdict: PN story over-reaches; appropriately NOT added. Review instead ADDED GO:0032042 (mtDNA metabolic process) and GO:0032543 (mitochondrial translation) as NEW — both better-supported core functions.
- **Mapping strategy:** Gene is a defensible decline at this node (parallel to RAB7A/HSPA8 broader-rejection precedent): the Mitophagy type-leaf mapping is a class-level statement, but this gene's role is suppressive/indirect, so the projected term (GO:0000423) is broader/wrong-signed relative to the review's evidence.
- **Evidence alignment:** No overlap. PN cites one mouse mitophagy paper (Atad3a/Pink1, Nat Immunology); review is built on mitochondrial topology/nucleoid/translation papers (PMID:20154147, 17210950, 22453275, 18063578) plus stress-signaling papers (PMID:37832546, 39116259) — none shared with the PN row. The projection rests on evidence the review judged insufficient for a human mitophagy assertion.
- **Verdict:** Consistent; PN mitophagy projection correctly NOT added (over-reaches; directionally suppressive in source). No edits required.