## ATG14
- **UniProt:** Q6ZNE5 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** 2 rows, ALP — (1) `Autophagophore initiation and elongation → Class 3 PI3K complex 1, direct → Class 3 PI3K complex 1 component`; (2) `Autophagosome closure maturation and lysosome fusion → Autophagosome-lysosome docking → Lysosome-autophagosome SNARE complex regulator`. **PN-node mapping:** component leaf=mapped→GO:0034271 (PI3KC3 type I); SNARE-regulator leaf=no_mapping; ancestors context_only (GO:0035032, GO:0061909, GO:0016236). **Projected:** GO:0034271 (more_specific_than_existing_goa).
- **Consistency:** Strongly consistent. The PN dual placement (early PI3KC3-C1 component + late STX17-SNAP29/VAMP8 fusion regulator) is exactly the two-function picture the review builds: PI3KC3-C1 recruitment/PI3P production AND ATG14-promoted autophagosome-endolysosome tethering/fusion (GO:0016240, GO:0097352 accepted; PMID:25686604). The projected GO:0034271 is precisely the review's MODIFY target — every GO:0035032 row is MODIFY→GO:0034271. No contradiction.
- **PN story / NEW pressure:** Already captured. The projected GO:0034271 is the review's own replacement term (not broader — it is *narrower* than existing GOA, the good direction). The late-fusion SNARE-regulator placement is already covered by accepted GO:0016240/GO:0097352. No new term warranted; PN adds no role the review lacks.
- **Mapping strategy:** No change needed. ATG14 strengthens the GO:0034271 mapping (it is the defining C1 subunit). The SNARE-regulator leaf's no_mapping is correct — ATG14's fusion role is already individually annotated, so leaf-level propagation would be redundant. This is the inverse of the TOMM20/HSPA8 over-reach pattern: here the projection is narrower than GOA, and the review agrees.
- **Evidence alignment:** Partial overlap. PN cites the Nature paper "ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes" = review's PMID:25686604 (heavily used). PN's two review-article citations (Annual Review; tandfonline) are not in the review, which instead uses primary literature (PMID:20713597, 21518905, 40442316, etc.). Convergent on the load-bearing paper.
- **Verdict:** Fully consistent; PN projection matches the review's own MODIFY. No edits needed.