## ATG2A
- **UniProt:** Q2TAZ0 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE (Falcon DR present)
- **PN placement:** `Autophagy-Lysosome Pathway|Autophagophore initiation and elongation|Regulation of autophagophore membrane composition|ATG2-WIPI complex component` ; **PN-node mapping:** type(ATG2-WIPI component)=mapped/ok GO:0062079 (ATG2-ATG18 complex, more_specific_than_existing_goa); group/branch=no_mapping; class=context_only GO:0016236 (macroautophagy). PN Notes: lipid transporter carrying phospholipids to phagophore, recruits ATG9. 5 reference titles (Atg2A-WIPI4 structure, lipid-droplet targeting, autophagosome biogenesis reviews).
- **Consistency:** Fully consistent. Deep research, notes, review YAML agree ATG2A is a rod-like bulk lipid-transfer/tethering protein bridging ER and phagophore, partnered with WIPI4/ATG18 and coupled to ATG9A scramblase. PN component placement (ATG2-WIPI complex) matches exactly. Review core = GO:0120013 lipid transfer + GO:0043495 protein-membrane adaptor → GO:0000045 autophagosome assembly.
- **PN story / NEW pressure:** PN projects GO:0062079 (ATG2-ATG18 complex), absent from GOA (more_specific_than_existing_goa). The review **accepted it as NEW (IDA)** — well-supported by ATG2A-WIPI4 evidence (PMID:31271352). Term verified real. **Conclude: ADD, already done in-review.** This is the well-behaved case: PN projects a MORE specific component term than existing GOA, and the review adopted it. No over-reach.
- **Mapping strategy:** ATG2A is a clean driver for the ATG2-WIPI component node; the type→GO:0062079 mapping is appropriately specific (more specific than existing GOA, opposite of the TOMM20/RAB7A "too broad" rejections). The notes correctly resisted broadening cargo-specific process terms (mitophagy/pexophagy/glycophagy IBA rows MODIFY'd toward general autophagosome assembly) and kept class-level macroautophagy as context_only. Sound strategy.
- **Evidence alignment:** PN reference titles (ATG2A-WIPI4 complex structure, ATG2 essential for autophagosome formation, lipid-droplet/early-autophagosome targeting) overlap the review's lipid-transfer core (PMID:30952800, PMID:31271352) and lipid-droplet non-core. PN refs are titles-only (not all PMIDs in review) but biologically concordant; no conflicts.
- **Verdict:** Consistent and well-supported; PN GO:0062079 correctly added as NEW. Exemplary specific-component projection. No edits warranted.