## ATP6AP1
- **UniProt:** Q15904 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** two rows, both leaf "Regulator of the lysosomal v-ATPase proton pump": (1) `ALP|Pre-initiation autophagy signaling|mTORC1 upstream|Nutrient sensing|...` and (2) `ALP|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|...`. **PN-node mapping:** leaves = mapped, GO:0060590 ATPase regulator activity (new_to_goa); plus type-node GO:0007042 lysosomal lumen acidification (already_in_goa_exact).
- **Consistency:** Deep research/notes, review, and PN agree: ATP6AP1/Ac45 is an accessory V0 assembly-hub/regulatory subunit (PMID:33065002, PMID:27231034). Review adds GO:0060590 (action NEW, IC) and ACCEPTs GO:0007042 — exactly matching both PN projections. Verified: GO:0060590 absent from goa.tsv (genuinely new); GO:0007042 present (NAS, ComplexPortal) confirming "already_in_goa_exact". No contradictions.
- **PN story / NEW pressure:** PN asserts a *regulator* MF not previously in GOA. Review correctly converts the legacy GO:0140677 (molecular function activator activity) → GO:0060590 and adds it as NEW core MF. GO:0060590 is a real term and the conservative right target (vs. uninformative protein binding, six of which are MARK_AS_OVER_ANNOTATED). **ADD GO:0060590 — implemented.**
- **Mapping strategy:** Gene meaningfully supports the leaf mapping (it is the archetypal "regulator of lysosomal V-ATPase"). Projected GO:0060590 is neither broader nor narrower than the review's chosen core MF — they coincide. GO:0007042 type-node projection matches existing GOA. Mapping is appropriate; no change.
- **Evidence alignment:** PN cites one title (Translational Neurodegeneration V-ATPase/lysosomal acidification review); review's supporting PMIDs (33065002 structural, 27231034 disease/localization, 22053050 mTORC1) are stronger and fully cover the claims. Minor: PN's single secondary-review citation is thinner than the review's primary set, but no conflict.
- **Verdict:** CONSISTENT — NEW GO:0060590 (verified real) appropriately added; PN leaf and acidification mappings align with review. No edits required.