## ATP6V0A1
- **UniProt:** Q93050 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** `ALP|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component` (also `...|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0...`) ; **PN-node mapping:** subtype `mapped`→GO:0046610 lysosomal V0 domain (Pre-init leaf, more_specific_than_existing_goa) / GO:0033179 V0 domain (Lysosomal leaf, already_in_goa_exact); type `mapped`→GO:0007042 lysosomal lumen acidification.
- **Consistency:** Consistent. Notes/review YAML, PN annotation, and PN-node mapping all describe ATP6V0A1 as the brain-enriched V0 a1-subunit of the lysosomal/synaptic-vesicle V-ATPase. Review ACCEPTs generic GO:0033179 ("already consistent with the PN projection") and ADDED GO:0046610 (action: NEW, IC, part_of) as the lysosome-specific refinement. No contradictions.
- **PN story / NEW pressure:** PN's lysosome-specific V0 term (GO:0046610) was more_specific_than_existing GOA; review correctly ADDED it, supported by ATP6V0A1 disease variants impairing lysosomal/endolysosomal acidification (PMID:33833240, 34909687). Generic V0 (GO:0033179) and acidification (GO:0007042) already captured. Verdict: one ADD (GO:0046610), rest already-captured — no over-reach.
- **Mapping strategy:** Gene supports node mapping; projected lysosomal-V0 term is narrower than the existing generic V0/complex annotations — an appropriate refinement. Notably the review used evidence code IC for the NEW row (vs TAS in the parallel ATP6V0C review) — a minor cross-gene inconsistency in how the same PN-derived lysosomal-V0 refinement is coded.
- **Evidence alignment:** PN cites the same V-ATPase/mTORC1 review set as ATP6V0C. Review anchors claims to gene-specific disease/functional papers (PMID:33833240 ATP6V0A1 variants; PMID:34909687 endolysosome acidification; PMID:33065002 structure) — more primary and gene-specific than the PN row. Convergent direction.
- **Verdict:** Consistent; PN lysosomal-V0 projection correctly ADDED (NEW GO:0046610). Optional: harmonize NEW-row evidence code with ATP6V0C (IC vs TAS).
- **Recommended edits:** [YAML] Consider aligning the GO:0046610 NEW-row evidence code between ATP6V0A1 (IC) and ATP6V0C (TAS) for consistency across the V0 PN refinements (low priority; both are defensible).