## ATP6V0B
- **UniProt:** Q99437 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** two ALP leaves "V0 lysosomal v-ATPase proton pump component" (under Nutrient sensing and under Lysosomal acidification). **PN-node mapping:** leaf→GO:0046610 lysosomal V-type ATPase V0 domain (more_specific_than_existing_goa); leaf→GO:0033179 proton-transporting V-type ATPase V0 domain (already_in_goa_exact); type→GO:0007042 lysosomal lumen acidification (already_in_goa_exact).
- **Consistency:** Deep research (falcon/openai/cyberian), review, and PN agree: ATP6V0B is the V0 c'' proteolipid (5-TM, conserved Glu98 essential for H+ transport; PMID:9653649, PMID:33065002). Review ACCEPTs GO:0033179, GO:0007042, GO:0046961 rotational activity, and adds GO:0046610 (action NEW, RCA) — matching all three PN projections. No contradictions.
- **PN story / NEW pressure:** PN asserts lysosome-specific V0-domain componency (GO:0046610) not yet in GOA. Review adds it as a conservative compositional refinement (existing V0-domain + lysosomal-membrane + lysosomal acidification already present). GO:0046610 is a real term; this is component specificity, not a new process claim. **ADD GO:0046610 — implemented.**
- **Mapping strategy:** Gene genuinely belongs at the leaf (bona fide V0 c'' subunit). GO:0046610 is *narrower* than ATP6V0B's existing generic V0/lysosomal annotations and is well supported, so unlike the TOMM20/RAB7A "too-broad" rejections this projection is defensible. No mapping change needed.
- **Evidence alignment:** PN cites V-ATPase/mTORC1 review titles (Regulation of mTORC1 by amino acids; SEA/GATOR; Eukaryotic V-ATPase; Translational Neurodegeneration). Review's anchors (PMID:9653649 Glu98, PMID:33065002 structure) are gene-specific and stronger; PN's mTORC1 titles support the nutrient-sensing context but are not gene-specific. No conflict.
- **Verdict:** CONSISTENT — NEW GO:0046610 (verified real, conservative narrowing) appropriately added; all leaf/type projections align with review. No edits required.