## ATP6V0D1
- **UniProt:** P61421 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** two ALP rows — `ALP|Pre-initiation autophagy signaling|mTORC1 pathway, upstream|Nutrient sensing|V0 lysosomal v-ATPase proton pump component` and `ALP|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|V0 lysosomal v-ATPase proton pump component` ; **PN-node mapping:** identical to ATP6V0A2 — V0 subtype leaves `mapped/ok_for_propagation` → GO:0046610, GO:0033179; Lysosomal-acidification type → GO:0007042; mTORC1/nutrient-sensing ancestors `no_mapping`; Pre-initiation class `context_only/too_broad` (GO:0010506).
- **Consistency:** Consistent. Notes, deep-research-manual, review, PN row and PN-node mapping all treat ATP6V0D1 as the d1 V0-sector subunit acidifying endolysosomal compartments. The review carries the mTORC1/Ragulator role as directly-evidenced (PMID:22053050, IDA) but KEEP_AS_NON_CORE, matching the PN ancestor `no_mapping`. No contradictions.
- **PN story / NEW pressure:** Unlike ATP6V0A2, ATP6V0D1 GOA already captures the lysosomal-specific terms: GO:0046611 lysosomal V-ATPase complex (IDA, PMID:22053050, ACCEPT) and GO:0007035 vacuolar acidification (IBA, ACCEPT) plus GO:1902600 proton transport. The two PN projected GO terms GO:0007042/GO:0046610 (both verified real via OLS) are therefore "more_specific" but the gene already has equivalent-or-adjacent coverage — review adds NO NEW terms (proposed_new_terms: []). No NEW pressure; the story is already captured. PN nutrient-sensing context is correctly represented only as non-core mTORC1 signaling, not promoted.
- **Mapping strategy:** No change. The node mapping is shared with ATP6V0A2 and stands; ATP6V0D1 does not push the node broader. Conservative `no_mapping` ancestors correct.
- **Evidence alignment:** Strong primary-evidence base, diverging from PN's review-title citations. Load-bearing PMIDs: 18752060 (d subunit central rotary role), 33065002 (human V-ATPase cryo-EM), 22053050 (mTORC1 amino-acid sensing, V0-d1/p18 interaction), 28296633 (iron/HIF), 11118322 (gene structure, full_text_unavailable flagged). PN's V-ATPase-structure and mTORC1 themes overlap conceptually but cite secondary reviews.
- **Verdict:** Consistent; PN projected terms already captured in GOA (GO:0046611/GO:0007035), so review correctly adds nothing; mTORC1 context kept non-core. No edits required.