## ATP6V0D2
- **UniProt:** Q8N8Y2 · **batch:** proteostasis-batch-2026-06-03 · **review status:** COMPLETE
- **PN placement:** two ALP leaves "V0 lysosomal v-ATPase proton pump component". **PN-node mapping:** leaf→GO:0046610 (more_specific_than_existing_goa); leaf→GO:0033179 (already_in_goa_exact); type→GO:0007042 lysosomal lumen acidification (more_specific_than_existing_goa).
- **Consistency:** Deep research (falcon), review, and PN agree: ATP6V0D2 is the d2 isoform of the V0 d subunit (PMID:18752060), tissue-restricted (kidney intercalated cells, osteoclasts; PMID:15800125), with newer ccRCC evidence for late-autophagy lysosomal acidification + RAB7/HOPS fusion (PMID:39477683). Review adds GO:0007042 (NEW, NAS) and GO:0046610 (NEW, IC) — matching both PN projections. No contradictions.
- **PN story / NEW pressure:** PN asserts lysosomal acidification + lysosomal V0-domain componency. For d2 these are genuinely new specificity beyond existing GO:0007035/GO:0033179, and PMID:39477683 gives gene-specific lysosomal-acidification support. Both terms verified real. The review flags appropriate caution (suggested_questions: should GO:0046610 propagate or await direct d2 lysosomal-complex evidence). **ADD GO:0007042 + GO:0046610 — implemented, with honest IC/uncertainty framing.**
- **Mapping strategy:** Gene supports the leaf (true V0 d2 subunit). GO:0046610 narrows existing annotations; GO:0007042 narrows GO:0007035 vacuolar acidification — both defensible narrowings, not over-broad. Note d2's strongest isoform-specific biology is *plasma-membrane* proton secretion (kidney/osteoclast), so lysosomal projection is real-but-context-dependent; review correctly keeps it as a conservative addition, not the sole core.
- **Evidence alignment:** PN cites generic V-ATPase/mTORC1 review titles; review adds the gene-specific PMID:18752060, PMID:15800125, PMID:39477683 absent from the PN reference list — a divergence where the review is better-sourced. No conflict.
- **Verdict:** CONSISTENT — both NEW terms (verified real) appropriately added as conservative narrowings; PN projections align with review. No edits required.