## ATP6V1A
- **UniProt:** P38606 · **batch:** proteostasis-batch-2026-06-06 · **review status:** COMPLETE (large, mature review; ~60 annotations curated)
- **PN placement:** `Autophagy-Lysosome Pathway|...|V1 lysosomal v-ATPase proton pump component` (two rows: mTORC1-upstream/Nutrient sensing, and Lysosomal acidification) ; **PN-node mapping:** subtype=mapped/ok GO:0046612 (V1 domain, lysosomal) + GO:0033176 (V-ATPase complex); type=mapped/ok GO:0007042 (lysosomal lumen acidification); ancestors no_mapping/context_only.
- **Consistency:** Strong. Deep research (notes) ↔ review ↔ PN all converge on: catalytic A subunit of V1, lysosomal/organellar acidification, and the mTORC1 amino-acid-sensing role (PMID:22053050) — the latter is exactly the PN "Nutrient sensing/mTORC1 upstream" story and is ACCEPTed in the review (GO:0071230, GO:0160124, GO:1904263). No contradictions: every PN-projected term is accepted in the review.
- **PN story / NEW pressure:** No new pressure. PN's mTORC1/nutrient-sensing assertion is already captured (3 ACCEPTed mTORC1 annotations). GO:0007042 already in GOA (dossier: already_in_goa_exact; confirmed 2 hits in GOA) and ACCEPTed. GO:0046612 (verified real via OLS, V1-domain lysosomal CC) is absent from GOA — a defensible more-specific ADD.
- **Mapping strategy:** A-subunit does not force a change to node mapping, but it sharpens it: review uses the **more specific** GO:0046611 "lysosomal V-type ATPase complex" (ACCEPT, IDA PMID:33065002/22053050), whereas the subtype-complex mapping targets the broader GO:0033176. The V1-domain target GO:0046612 is correctly the most specific.
- **Evidence alignment:** Divergent source sets, same conclusion. PN cites review-article titles (mTORC1 review, SEA/GATOR, Rubinstein V-ATPase review, neurodegeneration review). Review is anchored on primary/structural PMIDs: 33065002 (cryo-EM), 22053050 (Zoncu mTORC1), 32001091 (= Rubinstein review, overlap), 29668857, 28296633. PN's mTORC1-review evidence is the weaker-form counterpart of the review's Zoncu primary paper.
- **Verdict:** Consistent / ADD GO:0046612 (verified) as more-specific CC; no contradictions. **Recommended edits:** [MAP] align subtype complex target GO:0033176 → GO:0046611 (lysosomal V-ATPase complex, already ACCEPTed in review) for specificity.