## ATP6V1C1
- **UniProt:** P21283 · **batch:** proteostasis-batch-2026-06-06 · **review status:** COMPLETE (mature; ~35 annotations, no core_functions block but full annotation review)
- **PN placement:** `Autophagy-Lysosome Pathway|...|V1 lysosomal v-ATPase proton pump component` (two rows, identical pattern) ; **PN-node mapping:** subtype=mapped/ok GO:0046612 + GO:0033176; type=mapped/ok GO:0007042; ancestors no_mapping/context_only.
- **Consistency:** Consistent. Notes ↔ review agree: single-copy regulatory C subunit, required for V1 catalytic-sector assembly, ubiquitous (paralog C2 = testis). Review correctly ACCEPTs complex/process/MF core terms and marks regulation-of-macroautophagy and exosome HDA as over-annotated. No PN/review contradiction.
- **PN story / NEW pressure:** No over-reach. The PN mTORC1-upstream row is generic; the C1 review correctly does NOT add mTORC1/Ragulator annotations (no C1-specific evidence). GO:0007042 absent from C1 GOA (dossier: new_to_goa; confirmed 0 hits) — defensible ADD. GO:0046612 (verified real, OLS) absent — defensible more-specific ADD. GO:0033176 already in GOA (1 hit) and ACCEPTed.
- **Mapping strategy:** C1 does not change node mapping. C1's GOA lacks lysosomal-specific CC (GO:0046611 absent), so the broader GO:0033176 subtype-complex target is the correct safest choice here; the V1-domain projection GO:0046612 adds lysosomal specificity. Both projections additive and appropriate.
- **Evidence alignment:** Minimal overlap. PN cites generic V-ATPase/mTORC1 review titles; review anchors on C1-specific primaries: PMID:8250920 (C/D/E cloning), 12384298 (C/G/d isoforms), 16415858 (ARNO/Arf6 — correctly noted as V0 c-subunit not V1-C), 17897319 (lyso proteomics), 33065002. The 16415858 caveat (interaction attributed to other subunits) is a good catch unique to this review.
- **Verdict:** Consistent / ADD GO:0007042 + GO:0046612 (verified, new to C1 GOA); no contradictions. **Recommended edits:** none required; mappings sound.