## ATP6V1E1
- **UniProt:** P36543 · **batch:** proteostasis-batch-2026-06-06 · **review status:** COMPLETE (large, mature; ~45 annotations, full core_functions; one REMOVE flagged)
- **PN placement:** `Autophagy-Lysosome Pathway|...|V1 lysosomal v-ATPase proton pump component` (two rows, identical pattern) ; **PN-node mapping:** subtype=mapped/ok GO:0046612 + GO:0033176; type=mapped/ok GO:0007042; ancestors no_mapping/context_only.
- **Consistency:** Consistent. Notes ↔ review agree: E (with G) = peripheral-stalk stator; ALDOC/aldolase coupling (PMID:11399750); renal apical membrane (PMID:29993276, EXP/ACCEPT); ARCL2C disease (PMID:28065471); mTORC1 role as part of V1 (PMID:22053050, KEEP_AS_NON_CORE). PN's nutrient-sensing row is supported but appropriately non-core here. No PN/review contradiction.
- **PN story / NEW pressure:** No unmet PN pressure; review exceeds PN (aldolase/glycolysis coupling, renal acid-base) without conflict. GO:0007042 absent from E1 GOA (dossier: new_to_goa; confirmed 0 hits) — defensible ADD. GO:0046612 (verified real, OLS) absent — defensible more-specific ADD. Notable internal QC: review flags PMID:21784977 protein-binding annotation as a curation error → REMOVE (tristetraprolin/CCL3 paper, no ATP6V1E1 content) — a real data-quality catch, independent of PN.
- **Mapping strategy:** E1 does not change node mapping. E1 GOA carries GO:0046611 (1 hit, lysosomal complex, ACCEPTed) but not GO:0033176, so the subtype-complex projection of GO:0033176 is broader than the lysosomal-specific term the review already supports.
- **Evidence alignment:** Minimal overlap. PN cites generic review titles; review anchors on E1-specific primaries: PMID:11399750 (aldolase), 20717956 (RAB11B trafficking), 28065471 (ARCL2C), 29993276 (renal), 8250920 (cloning), 33065002. PN evidence non-E1-specific.
- **Verdict:** Consistent / ADD GO:0007042 + GO:0046612 (verified, new to E1 GOA); review also makes an unrelated REMOVE for a mis-attributed citation. **Recommended edits:** [MAP] consider subtype complex GO:0033176 → GO:0046611 (already ACCEPTed for E1) for specificity.