## AZI2
- **UniProt:** Q9H6S1 (NAP1/TBKBP2) · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE
- **PN placement:** `ALP|Autophagy substrate selection|Autophagy receptor regulation|Xenophagy` (1 row) ; **PN-node mapping:** Xenophagy type → mapped/ok_for_propagation_to_go GO:0098792 xenophagy (goa_status=new_to_goa); all ancestors (group/class/branch) = no_mapping.
- **Consistency:** Mostly consistent, with one framing mismatch. The review, notes and UniProt all cast NAP1 as a cytoplasmic TBK1/IKBKE adaptor and positive regulator (PMID:14560022), a shared antiviral type-I-IFN adaptor (PMID:17142768), and — structurally — a TBK1-recruiting adaptor for the autophagy cargo receptors NDP52/CALCOCO2 and TAX1BP1 (PMID:30459273). The PN row is keyed off exactly that NDP52/TAX1BP1-bridging literature ("recruiting the ULK complex"; CALCOCO2 in PN Notes). So the PN's xenophagy placement and the review's structural-adaptor finding agree on the underlying biology. The mismatch is in altitude/role: PN places AZI2 under "Autophagy receptor **regulation**" and projects the xenophagy **process** onto it, whereas the review treats autophagy as a peripheral structural role and assigns no autophagy term at all.
- **PN story / NEW pressure:** PN asserts a xenophagy role absent from GOA (confirmed: AZI2 GOA has no autophagy term). GO:0098792 xenophagy is verified real. But NAP1 is a TBK1-recruiting **adaptor/regulator**, not itself a cargo receptor or a demonstrated xenophagy effector in human cells — evidence is structural (bridges receptors to TBK1) rather than a loss-of-function xenophagy phenotype. Conclusion: a direct `involved_in xenophagy` over-reaches; `GO:1904415 regulation of xenophagy` (verified real) or leaving it as the TBK1-adaptor capture is more defensible than the bare process projection.
- **Mapping strategy:** Node need not change for this gene, but the projection is too strong: AZI2 supports the xenophagy node only as a TBK1-recruiting regulator. Prefer the regulation-of-xenophagy framing over `xenophagy` for this member.
- **Evidence alignment:** Partial. PN titles are the NDP52/CALCOCO2 ULK/TBK1 recruitment papers; the review's autophagy anchor is the NAP1-SKICH structural paper PMID:30459273 (HIGH relevance) plus the TBK1/IFN refs. The specific NDP52-ULK papers named in the PN dossier are not cited by PMID in the review.
- **Verdict:** Consistent biology, but PN xenophagy projection over-reaches for a TBK1-adaptor/regulator. **Recommended edits:** [MAP] downgrade AZI2's contribution to the Xenophagy node from `xenophagy` (GO:0098792, involved_in) to `regulation of xenophagy` (GO:1904415) — AZI2 is a TBK1-recruiting adaptor, not a cargo receptor. [YAML] optionally add GO:1904415 regulation of xenophagy (involved_in) supported by PMID:30459273 to reflect the NDP52/TAX1BP1-TBK1 bridging role; do not add bare GO:0098792.