## BCL2L13
- **UniProt:** Q9BXK5 · **batch:** proteostasis-batch-2026-06-06 · **review status:** COMPLETE
- **PN placement:** `Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy` ; **PN-node mapping:** Mitophagy type → mapped/ok_for_propagation GO:0000423 mitophagy (goa_status=new_to_goa); group/class/branch → no_mapping.
- **Consistency:** Consistent. PN (selective-autophagy/mitophagy receptor, Atg32 homolog binding LC3/ATG8 via LIR, induces fragmentation + Parkin-independent mitophagy), the review, notes and Falcon deep research all agree (PMID:26146385 Murakawa 2015; UniProt GABARAPL2 IntAct; PMID:36589739). PN Notes match the review description verbatim in substance.
- **PN story / NEW pressure:** PN projects GO:0000423 mitophagy as new_to_goa. The review notes UniProt/Ensembl GOA already carries GO:0000423 (IEA), but it is absent from the seeded existing_annotations — so adding the process is warranted (mild discrepancy: "new_to_goa" vs already-IEA-in-UniProt). The stronger NEW pressure is the **MF**: as with BNIP3L, the review proposes a new term "mitophagy receptor activity" stating the seeded set lacks any mitophagy MF. **GO:0140580 "mitochondrion autophagosome adaptor activity" already exists** and exactly captures the LIR-tethering activity — so the MF should be ADD GO:0140580, not a brand-new term. Conclusion: process partly captured (IEA), MF capturable by an existing real term that both PN and the review missed.
- **Mapping strategy:** Mitophagy type → GO:0000423 projection is appropriate for BCL2L13 (well-supported Atg32-homolog receptor). The shared-node projection is sound; this gene strengthens (does not over-broaden) the node, unlike rejected-broader precedents.
- **Evidence alignment:** PN cites the Murakawa Nat Commun mitophagy paper (=PMID:26146385) and a selective-autophagy ATG8/LIR review — both align with the review's references. Strong overlap. Deep research adds DRP1-dependent (GBM, PMID:37660127) vs DRP1-independent (Murakawa) context and MAM/Ca2+ role (PMID:39175772), none contradicting the mitophagy core.
- **Verdict:** Consistent; mitophagy process correctly added (note it is already IEA in UniProt GOA). Key finding: the review's proposed NEW "mitophagy receptor activity" duplicates existing **GO:0140580**. **Recommended edits:** [YAML][REF] replace the BCL2L13 proposed_new_term with existing GO:0140580 mitochondrion autophagosome adaptor activity (add as core MF, supported by PMID:26146385); [MAP] note GO:0000423 is already UniProt-IEA, so goa_status is closer to "already_in_goa" than "new_to_goa".
- **2026-06-18 follow-up:** Implemented the high-confidence YAML edits: added GO:0140580 mitochondrion autophagosome adaptor activity and GO:0000423 mitophagy as NEW recommendations, updated the core MF, and removed the duplicate mitophagy-receptor NTR block. Mapping goa_status cleanup remains separate.