## BNIP3L
- **UniProt:** O60238 · **batch:** proteostasis-batch-2026-06-06 · **review status:** COMPLETE
- **PN placement:** two rows — `Autophagy-Lysosome Pathway|Autophagy substrate selection|Selective autophagy receptor|Mitophagy` and `...|Autophagophore initiation and elongation|Class 3 PI3K complex 1, direct|Modulator of class 3 PI3K complex 1 activity|Modulator of BECN1 availability` ; **PN-node mapping:** Mitophagy type → mapped/ok GO:0000423 mitophagy (goa_status=supported_by_goa_regulation); BECN1-modulator path → context_only/too_broad GO:0035032 (class III PI3K complex), class → context_only GO:0016236.
- **Consistency:** Consistent. PN (mitophagy receptor + BECN1-availability modulator via atypical BH3), the review, notes and Falcon deep research all agree: NIX is an OMM tail-anchored mitophagy receptor (LIR→LC3/GABARAP; PMID:20200478) that under hypoxia also promotes pro-survival macroautophagy by disrupting Bcl-2-Beclin1 (PMID:19273585). PN row 1 = review core (mitophagy); PN row 2 = review's hypoxia/BECN1 axis. No contradictions.
- **PN story / NEW pressure:** PN row-1 GO:0000423 mitophagy is correctly "supported_by_goa_regulation" — the review carries GO:1901524 regulation of mitophagy (ACCEPT, IEA) so the process is already captured. The genuine NEW pressure is the **MF**: the review proposes a new term "mitophagy receptor activity" claiming none exists. This is incorrect — **GO:0140580 "mitochondrion autophagosome adaptor activity" already exists** (def "binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy"), exactly the LIR-tethering activity. So the MF is already captured by a real term; ADD GO:0140580 rather than a new term. BECN1-modulator (class III PI3K) row is correctly context_only (NIX modulates, is not a complex subunit).
- **Mapping strategy:** Row-1 mitophagy projection is fine (already in GOA via regulation term). Row-2 context_only/too_broad for GO:0035032 is correct (do not assign complex membership to a modulator) — consistent with the rejected-broader precedent.
- **Evidence alignment:** PN cites review-style titles (Marinkovic FEBS Open Bio 2021; hypoxia BH3 paper = PMID:19273585; mitophagy-initiation BST review). Review uses PMID:20200478, 19273585, 21264228, 9973195, plus FBXL4/PPTC7 turnover refs. Strong overlap on the hypoxia and receptor papers.
- **Verdict:** Consistent; mitophagy process already captured. Key finding: the review's proposed NEW "mitophagy receptor activity" term duplicates the existing **GO:0140580**. **Recommended edits:** [YAML][REF] replace the BNIP3L proposed_new_term "mitophagy receptor activity" with the existing GO:0140580 mitochondrion autophagosome adaptor activity (add as core MF, supported by PMID:20200478).