## CALR3
- **UniProt:** Q96L12 · **batch:** proteostasis-batch-2026-06-07 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone` ; **PN-node mapping:** identical to CLGN — leaf `[type] Lectin chaperone` `no_mapping`; `[group] N-glycosylation system` → `mapped` GO:0006487 protein N-linked glycosylation (`new_to_goa`); class/branch unmapped.
- **Consistency:** Consistent on identity (testis-specific calreticulin-family ER-lumen chaperone; calsperin/CRT2; client ADAM3; required for sperm fertility) across notes, YAML, and PN. Key point the YAML captures and PN does not: CALR3 does NOT bind calcium (negated GO:0005509, PMID:21590275, Stains-all) and UniProt flags it as a possibly *lectin-independent* chaperone — so the "Lectin chaperone" PN label is itself partly inaccurate for CALR3. Same GO:0006487 term-mismatch as CLGN.
- **PN story / NEW pressure:** PN's GO:0006487 projection over-reaches: CALR3 is a folding chaperone (binds clients), not an N-glycan-transfer enzyme, and is reported lectin-INdependent for ADAM3. The review's GO:0044183 protein folding chaperone, GO:0006457, GO:0007283 spermatogenesis, GO:0005788 ER lumen, and the NOT GO:0005509 capture the biology. GO:0006487 verified real but wrong-process → do not ADD.
- **Mapping strategy:** Same TOMM20-style over-reach as CLGN — the `N-glycosylation system` group projects a biosynthetic term onto a chaperone. Additionally, the `Lectin chaperone` leaf label conflicts with CALR3's documented lectin-independent mode, so even a lectin-specific mapping would be shaky. Recommend not propagating GO:0006487 to CALR3 and revisiting the leaf classification.
- **Evidence alignment:** PN listed no reference titles for this row. Review anchors on PMID:21590275 (ER-lumen localization + no Ca2+ binding) and UniProt; PMID:12384296 (identification, uncached) noted. No evidence conflict; the divergence is term/label choice.
- **Verdict:** Identity consistent, but PN GO:0006487 projection **over-reaches** (chaperone, not glycosyltransferase) and the `Lectin chaperone` label sits awkwardly with CALR3's lectin-independent, non-Ca2+ profile.

**Recommended edits:** [MAP] Do not propagate GO:0006487 to CALR3; remap `N-glycosylation system` group to a folding/glycoprotein-QC term or leave chaperone members unmapped. [MAP] Reconsider the `Lectin chaperone` leaf for CALR3 (documented lectin-independent). [YAML] No glycosylation annotation for CALR3.