## CAMLG
- **UniProt:** P49069 · **batch:** proteostasis-batch-2026-06-06 · **review status:** COMPLETE
- **PN placement:** two rows — `ER proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type` and `ER proteostasis|Protein transport|GET pathway component` ; **PN-node mapping:** GET group → mapped/ok_for_propagation GO:0006620 (post-translational targeting to ER membrane); Protein-transport class → mapped GO:0015031 protein transport; PPIase group/type → mapped GO:0003755 PPIase activity.
- **Consistency:** Partial conflict. The GET-pathway row is fully consistent: review, notes and deep research all establish CAMLG/CAML (GET2) as the mammal-specific subunit of the WRB/CAML/TRC40 GET insertase for tail-anchored proteins (PMID:23041287, 27226539, 32910895, 31417168). But PN row 1 classifies CAMLG as a **cyclophilin-type peptidyl-prolyl isomerase** projecting GO:0003755 (PPIase activity). The review, notes and UniProt give NO evidence CAML has PPIase activity — it was named for *binding* cyclophilin B (PMID:7522304), not for being one. PPIase projection to this gene is a misclassification.
- **PN story / NEW pressure:** GET-targeting role (GO:0006620, verified real) is correct and is NOT in current GOA as that exact term — review instead carries the better, more specific GO:0071816 (TA insertion into ER) and GO:0045048. So the GET process is already captured at gene level by a narrower term. GO:0003755 PPIase activity is an over-reach (no enzymatic evidence). Conclusion: GET row already captured (more specifically); PPIase row over-reaches.
- **Mapping strategy:** GET group mapping (GO:0006620, scope ok) is defensible but broader than the review's GO:0071816; treat as group-level only, do not project onto CAMLG (gene already has the specific term). The PPIase group/type mapping should NOT project onto CAMLG.
- **Evidence alignment:** PN row 1 cites no references; PN row 2 cites none. Review evidence (GET insertase PMIDs) does not overlap any PPIase literature, reinforcing the misclassification.
- **Verdict:** GET-pathway placement sound and already captured by a more specific gene-level term; PPIase classification is a misassignment — CAML binds cyclophilin B but is not a PPIase. **Recommended edits:** [MAP] flag CAMLG as a non-member of the PN "Peptidyl-prolyl isomerases / Cyclophilin type" node, or block GO:0003755 projection onto P49069 (binds cyclophilin, no isomerase activity).