## CCDC47
- **UniProt:** Q96A33 · **batch:** proteostasis-batch-2026-06-06 · **review status:** COMPLETE (excellent; review independently lands on PAT/MPT biology, notes present)
- **PN placement:** `ER proteostasis|Protein transport|Transmembrane protein import|PAT complex component` ; **PN-node mapping:** type (PAT complex component)→GO:0160005 PAT complex (mapped/ok); group (Transmembrane protein import)→GO:0044743 protein transmembrane import into intracellular organelle (mapped/ok); class (Protein transport)→GO:0015031 protein transport (mapped/ok).
- **Consistency:** Highly consistent. Review, notes, and PN all identify CCDC47 as the scaffold subunit of the PAT intramembrane-chaperone complex (obligate heterodimer with WDR83OS/Asterix) within the ribosome-associated multi-pass translocon (MPT). No contradictions.
- **PN story / NEW pressure:** GO:0160005 "PAT complex" is VERIFIED real (OLS def names CCDC47+Asterix heterodimer) and is NOT in CCDC47's GOA or review — the review used the broader parent GO:0160064 multi-pass translocon complex (IDA, PMID:36261522) and GO:0101031 protein folding chaperone complex. GO:0160005 is strictly more specific and exactly correct. Conclude: defensible ADD (the precise complex term). GO:0044743 / GO:0015031 are broader generalizations (transmembrane import / protein transport) that the review covers more specifically via GO:0160063 multi-pass TM insertion + GO:0045048 — already captured / broader.
- **Mapping strategy:** Node mapping is sound and laddered correctly (specific complex at type, broad process at class). The class/group terms are broader than the review (precedent: TOMM20/HSPA8/RAB7A broader-than-review rejections) — treat GO:0044743/GO:0015031 as context-only, not as gene-level GO assertions superseding the review's specific terms. The type-level GO:0160005 is the value-add.
- **Evidence alignment:** PN node carries no reference titles; review/GOA anchored on the defining primary literature (PMID:32814900 PAT discovery, PMID:36261522 MPT assembly, PMID:32820719 ribosome-Sec61 translocon). The PAT-complex term itself originates from this same literature, so PN and review are evidence-aligned even without shared citation strings.
- **Verdict:** Consistent; PN adds the precise complex term. **Recommended edits:** [YAML] ADD GO:0160005 PAT complex (part_of, IPI/IDA, PMID:32814900/PMID:36261522) to CCDC47 existing_annotations and core_functions.in_complex — it is the exact, more-specific complex vs the review's GO:0160064. [MAP] keep GO:0044743/GO:0015031 as context-only (broader than review's GO:0160063/GO:0045048).