## CCDC50
- **UniProt:** Q8IVM0 (Ymer) · **batch:** proteostasis-batch-2026-06-14 · **review status:** COMPLETE (~239 lines, small)
- **PN placement:** ALP `Autophagy substrate selection|Selective autophagy receptor|Individual substrates` + UPS `Ubiquitin and UBL binding|trafficking|macroautophagy|MIU` ; **PN-node mapping:** Individual substrates→GO:0160247 cargo adaptor (new_to_goa); UPS macroautophagy type→GO:0016236 context_only; ancestors no_mapping/context_only.
- **Consistency:** Consistent at the conclusion level but with an evidence-source divergence. PN row 1 rests on ONE paper — "CCDC50 suppresses NLRP3 inflammasome... autophagic degradation of NLRP3" (EMBO reports) — delivering ubiquitinated NLRP3 to autophagosomes. The review/notes do NOT cite that EMBO paper; instead the autophagy-receptor role is built from K63-polyUb binding (PMID:18029035), RNF126/EGFR sorting (PMID:23418353), and a literature-level "TBK1-binding SLR in aggrephagy/reticulophagy / RIG-I-MAVS turnover" framing (Hou et al. Autophagy 2021, not cached). Both routes converge on the same MF.
- **PN story / NEW pressure:** PN and review AGREE on the new MF: GO:0160247 autophagy cargo adaptor activity (verified real) is **new_to_goa** in PN and **proposed_new_terms** in the review (proposed child "K63-linked polyubiquitin selective autophagy receptor activity" under GO:0160247, supported_by PMID:18029035). Clear ADD, well-justified — current GOA has only ubiquitin-ligase binding (GO:0031625) and bare protein binding.
- **Mapping strategy:** Mapping is correct (KEY PATTERN: elevate cargo-adaptor MF over bare protein binding, ~2 IPI kept non-core). PN GO:0160247 = review proposed parent. Sound, not an over-reach.
- **Evidence alignment:** DIVERGENT references — PN cites the EMBO NLRP3 paper; review cites NF-kB/EGFR/K63 papers. Same destination, different supporting literature; the EMBO NLRP3 paper would strengthen the review's NEW-term justification.
- **Verdict:** CONSISTENT conclusion (GO:0160247 ADD agreed by both); evidence sources diverge. **Recommended edits:** [REF] add the CCDC50/NLRP3 autophagic-degradation EMBO reports paper to the review references and as supporting_text for the proposed GO:0160247 receptor MF.