## CHAF1B
- **UniProt:** Q13112 · **batch:** proteostasis-batch-2026-06-07 · **review status:** COMPLETE
- **PN placement:** `Nuclear proteostasis|Chaperone|Histone chaperone` ; **PN-node mapping:** Histone-chaperone group→GO:0140713 histone chaperone activity (new_to_goa). Chaperone class + NU branch = no_mapping.
- **Consistency:** Strong. Review, notes, PN annotation and node mapping all agree CHAF1B (p60) is the WD40 medium subunit of the CAF-1 H3-H4 chaperone (bridges CHAF1A/p150 and RBBP4/p48; binds H3.1/H3.2/H3.1t), acting in replication-coupled nucleosome assembly. The review already carries GO:0140713 "histone chaperone activity" as a NEW (IC) annotation — matching the PN projection exactly. No contradictions.
- **PN story / NEW pressure:** PN projects GO:0140713 (verified real) as new_to_goa — confirmed: CHAF1B GOA captures histone contacts as histone binding (GO:0042393, NAS) and bare protein binding, but lacks the MF histone-chaperone-activity term. Already independently flagged ADD in the review (NEW GO:0140713; GO:0042393 retained as core). PN and review converge; nothing over-reaches.
- **Mapping strategy:** Group-level mapping to the precise MF GO:0140713 (rather than broad "Nuclear proteostasis"/"Chaperone") is correct and avoids over-propagation. Same placement as CHAF1A; appropriate. No change needed.
- **Evidence alignment:** PN row carries no explicit reference list; the projected MF rests on the same CAF-1 evidence the review uses (PMID:7600578 p150/p60 + newly synthesized H3/acetyl-H4; PMID:8858152, PMID:14718166; UniProt H3.1/H3.2/H3.1t). Concordant; no divergence. Other interactome PMIDs (BioPlex etc., all ASF1A/B) are correctly MARK_AS_OVER_ANNOTATED.
- **Verdict:** CONSISTENT — PN GO:0140713 already captured by the review's NEW annotation. **Recommended edits:** none (review and PN aligned).