## CHMP4C
- **UniProt:** Q96CF2 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP → Autophagosome closure maturation and lysosome fusion → Sealing of autophagophore membrane → ESCRT-III complex component` AND `ALP → Microautophagy → General microautophagy machinery → ESCRT-III complex component` (2 rows; identical template to CHMP4B/5/6/7)
- **PN-node mapping:** type → GO:0000815 ESCRT III complex (`already_in_goa_exact`); "Sealing" group → GO:0000045 autophagosome assembly (`more_specific_than_existing_goa`); classes `context_only`/`too_broad` (GO:0016236, GO:0016237); branch `no_mapping`.
- **Consistency:** Consistent, with a deliberate emphasis divergence the review handles well. The review's core function is the specialized Aurora-B/NoCut **abscission-checkpoint** role (midbody, Borealin/CPC, ANCHR/ZFYVE19, VPS4 retention), NOT autophagosome sealing. The PN places CHMP4C in the generic ESCRT-III sealing bucket purely by family/component membership; the review's autophagy entries (GO:0097352, GO:0016236) are explicitly KEEP_AS_NON_CORE and flagged as inherited, "cached CHMP4C-specific papers do not directly test CHMP4C as the phagophore sealing effector." No contradiction — the review is correctly more conservative than PN.
- **PN story / NEW pressure:** PN projects GO:0000045 autophagosome assembly (verified real). For CHMP4C the supporting evidence is paralog/family-level only, so this would be over-reach as a gene-specific assertion. The review already captures the family context as non-core and raises a `suggested_question` asking which assays directly implicate CHMP4C vs family inclusion. **PN over-reaches for CHMP4C — do not ADD GO:0000045; already captured at non-core altitude.**
- **Mapping strategy:** No change. CHMP4C is a weak member for the "Sealing" group projection; the conservative class-level `context_only` is right and the gene's distinctive checkpoint role is orthogonal to the ALP-sealing node.
- **Evidence alignment:** Divergent. PN cites the Cells "Key Regulators of Autophagosome Closure" review only. Review cites primary checkpoint/ESCRT papers (PMID:36107470 ESCRT-III-MIT interactome [eLife, verified — not the PN review], PMID:17984323, PMID:20588296). No shared citations.
- **Verdict:** Consistent; review correctly resists the PN autophagy projection. **Recommended edits:** none.