## CHMP5
- **UniProt:** Q9NZZ3 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP → Autophagosome closure maturation and lysosome fusion → Sealing of autophagophore membrane → ESCRT-III complex component` AND `ALP → Microautophagy → General microautophagy machinery → ESCRT-III complex component` (2 rows; shared CHMP template)
- **PN-node mapping:** type → GO:0000815 ESCRT III complex (`already_in_goa_exact`); "Sealing" group → GO:0000045 autophagosome assembly (`more_specific_than_existing_goa`); classes `context_only`/`too_broad`; branch `no_mapping`.
- **Consistency:** Consistent. The review frames CHMP5 not as a polymerizing core subunit but as a SNF7-family ESCRT-III-**associated regulator** that links LIP5/VTA1 to VPS4 disassembly. Its description explicitly says evidence does not support a "general CHMP5-specific autophagosome maturation mechanism." PN's component-bucket placement and the review's regulatory framing are compatible; the review is appropriately more cautious than the PN's blanket "ESCRT-III complex component" label.
- **PN story / NEW pressure:** PN projects GO:0000045 autophagosome assembly (verified real). CHMP5 support is family/regulatory-inheritance only (autophagosome maturation is IEA/GO_REF:0000117, KEEP_AS_NON_CORE). A gene-specific GO:0000045 assertion would be over-reach; the review already captures the autophagy context as non-core and asks (suggested_question) which CHMP5 autophagy annotations rest on direct closure/maturation assays. **PN over-reaches for CHMP5 — already captured; do not ADD.**
- **Mapping strategy:** No change. CHMP5's regulatory (LIP5/VPS4) role differs from the structural "ESCRT-III complex component" leaf; class-level `context_only` is correct and the GO:0000815 leaf is the most CHMP5-defensible part of the projection.
- **Evidence alignment:** Divergent. PN cites only the Cells "Key Regulators of Autophagosome Closure" review. Review cites primary ESCRT/regulatory literature (incl. PMID:36107470 ESCRT-III-MIT interactome [verified, not the PN review], PMID:17984323). No shared specific citations; same broad theme.
- **Verdict:** Consistent; review appropriately conservative on the PN autophagy projection. **Recommended edits:** none.