## CHMP6
- **UniProt:** Q96FZ7 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP → Autophagosome closure maturation and lysosome fusion → Sealing of autophagophore membrane → ESCRT-III complex component` AND `ALP → Microautophagy → General microautophagy machinery → ESCRT-III complex component` (2 rows; shared CHMP template)
- **PN-node mapping:** type → GO:0000815 ESCRT III complex (`already_in_goa_exact`); "Sealing" group → GO:0000045 autophagosome assembly (`more_specific_than_existing_goa`); classes `context_only`/`too_broad`; branch `no_mapping`.
- **Consistency:** Consistent. The review identifies CHMP6 as the human Vps20 ortholog — the myristoylated ESCRT-II→ESCRT-III **nucleator/acceptor** (bridges ESCRT-II to CHMP4 polymerization), which is mechanistically upstream of sealing rather than the sealing effector itself. PN's generic component placement and the review's nucleator framing agree; autophagy entries (GO:0097352 IEA, GO:0016236 TAS PMID:20588296) are KEEP_AS_NON_CORE. No contradiction.
- **PN story / NEW pressure:** PN projects GO:0000045 autophagosome assembly (verified real). CHMP6 support is family/role-inheritance, not a CHMP6-specific closure assay; the review explicitly states "cached evidence does not make CHMP6-specific autophagosome maturation the core function" and raises a suggested_question on this. A gene-specific GO:0000045 would over-reach. **PN over-reaches for CHMP6 — already captured at non-core altitude; do not ADD.**
- **Mapping strategy:** No change. CHMP6's nucleation role fits the ESCRT-III-complex leaf (GO:0000815) well, but its upstream position makes the "Sealing" group→GO:0000045 projection a poor gene-specific fit; class-level `context_only` is the right ceiling.
- **Evidence alignment:** Divergent. PN cites only the Cells "Key Regulators of Autophagosome Closure" review. Review cites primary literature (PMID:15511219 CHMP6/ESCRT-II acceptor, PMID:17984323, PMID:20588296, PMID:36107470 [verified]). No shared specific citations.
- **Verdict:** Consistent; review correctly distinguishes CHMP6's nucleator role from generic sealing and resists the autophagy projection. **Recommended edits:** none.