## CHMP7
- **UniProt:** Q8WUX9 · **batch:** proteostasis-pr-1217 · **review status:** COMPLETE
- **PN placement:** `ALP → Autophagosome closure maturation and lysosome fusion → Sealing of autophagophore membrane → ESCRT-III complex component` AND `ALP → Microautophagy → General microautophagy machinery → ESCRT-III complex component` (2 rows; shared CHMP template)
- **PN-node mapping:** type → GO:0000815 ESCRT III complex (`already_in_goa_exact`); "Sealing" group → GO:0000045 autophagosome assembly (`more_specific_than_existing_goa`); classes `context_only`/`too_broad`; branch `no_mapping`.
- **Consistency:** Mostly consistent, with a real specificity tension. The review identifies CHMP7 as an ESCRT-II/ESCRT-III **hybrid** whose most specific role is **nuclear-envelope hole sealing** via LEMD2 binding and CHMP4B recruitment — not autophagosome closure. PN lumps CHMP7 into the generic ESCRT-III sealing/microautophagy component buckets. The review's autophagy entries (GO:0097352 IEA, KEEP_AS_NON_CORE) are flagged as "plausible secondary ESCRT pathway / broad location context." The PN-vs-review divergence is in emphasis (NE sealing vs autophagosome sealing), not factual contradiction.
- **PN story / NEW pressure:** PN projects GO:0000045 autophagosome assembly (verified real); for CHMP7 the support is family/membership-level, so a gene-specific assertion would over-reach. Notably the review's own NEW pressure is elsewhere — a suggested_question asks for a more specific GO term for ESCRT-mediated **nuclear-envelope hole sealing during anaphase** (proposed_new_terms is empty; that is a candidate, unverified gap). **PN over-reaches on autophagy for CHMP7 — already captured non-core; do not ADD GO:0000045.**
- **Mapping strategy:** No change to the ALP node. CHMP7's distinctive function is nuclear-envelope/ESCRT-II-III hybrid, peripheral to the autophagosome-sealing node; GO:0000815 leaf is defensible, the "Sealing" group→GO:0000045 projection is a weak gene-specific fit (class `context_only` is the correct ceiling).
- **Evidence alignment:** Divergent. PN cites only the Cells "Key Regulators of Autophagosome Closure" review. Review cites primary ESCRT/NE-sealing literature (incl. PMID:36107470 ESCRT-III-MIT interactome [verified, not the PN review]). No shared specific citations.
- **Verdict:** Consistent; review correctly centers NE sealing and treats PN's autophagy placement as non-core. **Recommended edits:** none for autophagy; (optional, out-of-scope) the NE-hole-sealing GO gap the review flags is worth pursuing separately.