## CLCN7
- **UniProt:** P51798 · **batch:** proteostasis-batch-2026-06-07 · **review status:** COMPLETE
- **PN placement:** `Autophagy-Lysosome Pathway|Lysosomal catabolism|Regulation of lysosomal environment|Lysosomal acidification|Miscellaneous function - lysosomal acidification` ; **PN-node mapping:** the leaf and most ancestors are `no_mapping`; the `[type]` node "Lysosomal acidification" is `mapped`, `ok_for_propagation_to_go`, GO:0007042 lysosomal lumen acidification (verified real; not in GOA → `new_to_goa`).
- **Consistency:** Strongly consistent. Deep-research notes, review YAML, and PN row all describe ClC-7 as the 2Cl(-)/1H(+) lysosomal antiporter (not a passive channel) that supports V-ATPase acidification. The single PN reference (PMID:18449189, "primary chloride permeation pathway in lysosomes") is the central paper in both the notes and the YAML. No contradictions.
- **PN story / NEW pressure:** PN emphasizes ClC-7's contribution to lysosomal acidification (GO:0007042), which is absent from existing GOA. The review captures the molecular mechanism (GO:0062158 antiporter; GO:1902600 proton transport) but does NOT annotate the acidification process itself. GO:0007042 is a defensible, verified ADD — directly supported by PMID:18449189 (siRNA knockdown diminishes lysosomal acidification). Note the literature nuance (normal steady-state pH in Clcn7-/- mice; PMID:32851177) means an `involved_in` (contributory), not causal, framing is appropriate.
- **Mapping strategy:** No change needed. The PN node maps at the correct (`type`) altitude with conservative parents left unmapped. GO:0007042 is neither broader than the review nor a TOMM20-style over-reach; it is a genuine process gap.
- **Evidence alignment:** Full overlap on PMID:18449189. Review additionally cites PMID:21527911 (stoichiometry), PMID:32851177 (cryo-EM/complex). No divergence.
- **Verdict:** Consistent; **ADD** GO:0007042 lysosomal lumen acidification (involved_in) to the review.

**Recommended edits:** [YAML] Add an `existing_annotations`/`proposed_new_terms` entry or `core_functions.directly_involved_in` for GO:0007042 lysosomal lumen acidification (involved_in, supported_by PMID:18449189), framed as contributory.