## CLGN
- **UniProt:** O14967 · **batch:** proteostasis-batch-2026-06-07 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis|Glycoproteostasis|N-glycosylation system|Lectin chaperone` ; **PN-node mapping:** leaf `[type] Lectin chaperone` `no_mapping`; `[group] N-glycosylation system` → `mapped` GO:0006487 protein N-linked glycosylation (`new_to_goa`); class/branch unmapped.
- **Consistency:** Mostly consistent on identity (testis-specific calnexin-family lectin-type ER membrane chaperone; clients = ADAM1/2/ADAM3; essential for sperm-zona binding/fertility) across notes, YAML, and PN. The friction is the projected GO term: the PN node projects GO:0006487 (the biosynthetic process that *adds* N-glycans), but CLGN is a lectin chaperone that *binds* monoglucosylated N-glycans on clients — it does not catalyze glycan transfer. The review correctly annotates GO:0044183 protein folding chaperone / GO:0006457 protein folding, not glycosylation.
- **PN story / NEW pressure:** PN's "N-glycosylation system" framing over-reaches when projected as GO:0006487 for a lectin chaperone. CLGN's real, review-captured roles (folding chaperone, single fertilization GO:0007338) are already in GOA/review. GO:0006487 is verified real but is the WRONG process for this gene's mechanism → over-reaches; do not ADD to the gene.
- **Mapping strategy:** The `[group]` projection is the problem. GO:0006487 is broader/orthogonal to what lectin chaperones do; it is analogous to the TOMM20/HSPA8/RAB7A "broader, rejected" precedent — the node groups the N-glycosylation machinery but its members (OST subunits vs lectin chaperones) do not share GO:0006487. Recommend the group either map to a glycoprotein-QC/folding term (e.g. a chaperone-mediated folding concept) or leave lectin-chaperone members unmapped at this node, so GO:0006487 is not propagated to CLGN.
- **Evidence alignment:** PN listed no reference titles for this row. Review anchors on PMID:9177349 (knockout/zona-adhesion), PMID:17507649 (PDILT complex), PMID:9434179 (cloning). No conflict; the divergence is term choice, not evidence.
- **Verdict:** Identity consistent, but PN GO:0006487 projection **over-reaches** for a lectin chaperone (binds, not synthesizes, N-glycans); should not propagate to CLGN.

**Recommended edits:** [MAP] Do not propagate GO:0006487 from `N-glycosylation system` to lectin-chaperone members (CLGN); remap the group to a folding/glycoprotein-QC term or leave lectin chaperones unmapped. [YAML] No glycosylation annotation should be added to CLGN.