## COLGALT2
- **UniProt:** Q8IYK4 · **batch:** proteostasis-batch-2026-06-07 · **review status:** COMPLETE
- **PN placement:** `ER proteostasis | Maturation and folding of specific substrates | ER collagen processing and folding` ; **PN-node mapping:** group=mapped, scope=ok_for_propagation_to_go, GO:0032964 collagen biosynthetic process (class/branch = no_mapping)
- **Consistency:** Consistent. Review, PN annotation, and PN-node mapping agree: COLGALT2/GLT25D2 is a soluble ER-luminal, Mn2+-dependent collagen beta(1-O)galactosyltransferase (EC 2.4.1.50), paralog of COLGALT1, brain/skeletal-muscle-enriched. No contradictions.
- **PN story / NEW pressure:** PN projects GO:0032964 collagen biosynthetic process (verified real OLS). Review captures the more specific GO:0050211 procollagen galactosyltransferase activity (MF) and proposes GO:0180062 protein O-linked glycosylation via galactose as a NEW BP (replacing reliance on the downstream GO:0030199). The PN pathway context is consistent with and broader than these. Conclusion: **already captured** (review goes finer-grained); no PN-driven NEW pressure.
- **Mapping strategy:** No change. Group-node → GO:0032964 is the same defensible shared-pathway mapping as for COLGALT1/CRTAP/P3H1 in this collagen-processing group; appropriate process-level umbrella, ancestors correctly no_mapping. The review's NEW GO:0180062 would be the more precise gene-level BP but does not change the node mapping.
- **Evidence alignment:** PN row has no reference titles; review's enzymatic evidence rests mainly on PMID:19075007 and UniProt (plus high-throughput protein-binding PMIDs marked over-annotated). Collagen-biosynthesis evidence base is thinner than COLGALT1's but adequate and concordant with the mapping. No divergence.
- **Verdict:** Consistent; PN collagen-biosynthesis role already captured (more specifically) in review. No edits required.