## COP1
- **UniProt:** Q8NHY2 (RFWD2) · **batch:** proteostasis-batch-2026-06-07 · **review status:** COMPLETE (40 annotations reviewed)
- **PN placement:** two rows — (1) `UPS|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate adaptor|WD40|other`; (2) `UPS|E3 ubiquitin and UBL ligases|RING|RFWD|WD40` ; **PN-node mapping:** group nodes mapped — Cul4 adaptor group → GO:1990756 (substrate-adaptor MF); RING group → GO:0061630 (catalytic ligase MF); both ok_for_propagation.
- **Consistency:** Strong. The PN dual classification (catalytic RING E3 *and* CRL4 substrate adaptor) exactly matches the review's two core_functions: GO:0061630 ubiquitin protein ligase activity (EXP PMID:12615916, IMP PMID:19805145) and GO:1990756 substrate-adaptor activity (WD40 propeller; PMID:14739464, PMID:21572435). Deep-research notes, review YAML, and PN annotation agree COP1 is both stand-alone RING (catalytic) and the substrate-recognition subunit of DCX(DET1-COP1) CRL4 (RBX1 catalytic). No contradictions.
- **PN story / NEW pressure:** No NEW pressure. Both projected terms are already present/captured: GO:0061630 is in existing_annotations (EXP/IMP/IEA, ACCEPT, core); GO:1990756 is asserted as a core_function (proposed_new_terms is empty because the term already exists and is used). PN's "new_to_goa" flag on GO:1990756 reflects that GOA lacks the explicit adaptor MF, but the review already proposes it. Already captured.
- **Mapping strategy:** Correct and well-calibrated. This gene is the precedent for distinguishing the two MFs: RING group → catalytic GO:0061630; Cul4 adaptor group → GO:1990756. Both group-level mappings fit COP1; class/branch correctly context_only/no_mapping. No change needed.
- **Evidence alignment:** PN cites only review-stub PMIDs (17588513 = the DCAF discovery review for the Cul4 row; 19489725 = ER-RING-ligase screen for the RING row). Review's substantive evidence (PMID:12615916, 14739464, 19805145, 21572435, 39920308) does not overlap PN's two citations, but PN citations are family/architecture references, not gene-specific — divergence is expected and benign.
- **Verdict:** Consistent; mapping sound; no edits. COP1 correctly carries both catalytic and adaptor MFs.