## DCAF10
- **UniProt:** Q5QP82 (WDR32) · **batch:** proteostasis-batch-2026-06-07 · **review status:** COMPLETE
- **PN placement:** `UPS|E3 ubiquitin and UBL ligases|Cul4A/Cul4B substrate receptor|WD40|other` ; **PN-node mapping:** group node `Cul4A/Cul4B substrate receptor` mapped → GO:1990756 ubiquitin-like ligase-substrate adaptor activity (ok_for_propagation, new_to_goa); class context_only (GO:0061630, too_broad).
- **Consistency:** Consistent. Deep-research notes, review, and PN all describe DCAF10 as a poorly characterized (Pharos Tdark) WD40 substrate-recognition receptor that docks DDB1 of CRL4 via WDxR; direct evidence limited to DDB1/CUL4 co-purification (PMID:16949367, IDA/NAS); only proposed substrate is MCL1 from a single non-replicated ESCC/OTUD1 study (PMID:33898171). No contradictions.
- **PN story / NEW pressure:** Genuine ADD pressure. The review's core_function for DCAF10 carries NO molecular_function term (only a complex-membership description) and the existing GOA has no MF beyond bare protein binding (all MARK_AS_OVER_ANNOTATED). PN's projected GO:1990756 (verified real via OLS) is exactly the substrate-adaptor MF this receptor should carry by analogy with the DCAF family and is defensible even for a Tdark gene given direct DDB1/CUL4 association. Recommend ADD as inferred (ISS/IBA-style) MF. Distinct from COP1: DCAF10 is a pure substrate-adaptor (no catalytic RING) → GO:1990756, NOT GO:0061630.
- **Mapping strategy:** Correct. Group-level GO:1990756 is appropriate (substrate receptor, not catalytic), class-level GO:0061630 correctly held as too_broad. Projected term is neither broader nor narrower than warranted — it is the precise missing MF. No mapping change; this gene strengthens the node.
- **Evidence alignment:** PN cites 17588513 (DCAF discovery review). Review's key gene-specific evidence is PMID:16949367 (founding DCAF paper) and PMID:33898171 (MCL1). Partial conceptual overlap (both family-level), no direct PMID match.
- **Verdict:** Consistent; mapping sound. NEW MF pressure is real and defensible — GO:1990756 should be added to the review.
- **Recommended edits:** Add GO:1990756 (ubiquitin-like ligase-substrate adaptor activity) as the molecular_function on DCAF10's core_function, inferred by homology/DCAF-family membership. [YAML]